diff --git a/.github/scripts/validate_mappings.py b/.github/scripts/validate_mappings.py
index db75d1a..6577aeb 100644
--- a/.github/scripts/validate_mappings.py
+++ b/.github/scripts/validate_mappings.py
@@ -5,7 +5,9 @@
predictor's `mappings/ari.synonym_blocklist.tsv` for
structural problems, malformed identifiers and internal contradictions, that
the two files agree with each other, and that both agree with the stored
-cross-references in `ontologies/ari_t1d.owl`.
+cross-references in `ontologies/ari_t1d.owl`. Also checks that every Symptom
+individual's `symptomConcept` agrees with
+`notebook/symptom-mapping/symptom_mapping.tsv`.
Usage:
python .github/scripts/validate_mappings.py # audit everything
@@ -43,6 +45,15 @@
# beside it is the generated evidence behind these decisions and is a report, so
# nothing here validates it.
BLOCKLIST_PATH = "mappings/ari.synonym_blocklist.tsv"
+# Curated symptom string -> shared ARI symptom (ARIS) table. Every Symptom
+# individual in the ontology links its row's ARIS class with symptomConcept,
+# which notebook/symptom-mapping/build_symptom_mapping.py writes.
+SYMPTOM_MAPPING_PATH = "notebook/symptom-mapping/symptom_mapping.tsv"
+SYMPTOM_MAPPING_COLUMNS = [
+ "Symptom ID", "Symptom", "Mapping", "SYMP ID", "SYMP Label",
+ "HPO ID", "HPO Label", "HPO Mapping", "Parent Symptom", "Merged Into",
+]
+ARIS_BASE = "http://www.aurint.org/ontologies/ari-symptoms#"
SSSOM_COLUMNS = [
"subject_id",
@@ -163,6 +174,7 @@
ANNOTATION_RE = re.compile(r"<(ARI_\w+)[^>]*>(.*?)\1>")
LABEL_RE = re.compile(r"]*>(.*?)")
CURIE_MAP_RE = re.compile(r"#\s{2,}([A-Za-z0-9_.]+):\s")
+SYMPTOM_CONCEPT_RE = re.compile(r'')
@dataclass(frozen=True)
@@ -1225,6 +1237,92 @@ def check_blocklist(rows: list[Row], diseases: dict[str, Disease] | None, report
)
+def expected_symptom_concepts(rows: list[Row], report: Report) -> dict[str, str | None]:
+ """Symptom string -> the ARIS class IRI its individuals link to; None for `not a symptom`."""
+ by_name = {row.fields["Symptom"]: row for row in rows}
+ expected: dict[str, str | None] = {}
+ for name, row in by_name.items():
+ target = row.fields["Merged Into"]
+ if target and target not in by_name:
+ report.error(
+ "symptom-merge-target", SYMPTOM_MAPPING_PATH, row.line,
+ f"{name!r} is merged into {target!r}, which has no row.",
+ )
+ continue
+ symptom_id = by_name[target].fields["Symptom ID"] if target else row.fields["Symptom ID"]
+ expected[name] = ARIS_BASE + symptom_id.replace(":", "_") if symptom_id else None
+ return expected
+
+
+def check_symptom_concepts(text: str, rows: list[Row], report: Report) -> None:
+ """Every Symptom individual links the shared symptom its label maps to.
+
+ The label is the key: symptom_mapping.tsv owns which ARIS class a symptom
+ string is, and symptomConcept is that decision applied to each per-disease
+ individual. Findings sit on the label line, since a renamed label is what
+ leaves a link stale. A label with no row yet, or a mapped label not linked
+ yet, is a warning: the curator added a symptom and the mapping catches up.
+ A link that disagrees with the row is an error.
+ """
+ expected = expected_symptom_concepts(rows, report)
+ current: dict | None = None
+ for index, line in enumerate(text.replace("\r\n", "\n").split("\n"), start=1):
+ open_match = ENTITY_OPEN_RE.match(line)
+ if open_match and not line.rstrip().endswith("/>"):
+ current = {
+ "close": f"{open_match.group(1)}>",
+ "symptom": open_match.group(1) == "Symptom",
+ "label": None,
+ "line": index,
+ "concepts": [],
+ }
+ continue
+ if current is None:
+ continue
+ if '' in line:
+ current["symptom"] = True
+ label_match = LABEL_RE.search(line)
+ if label_match:
+ current["label"] = html.unescape(label_match.group(1)).strip()
+ current["line"] = index
+ current["concepts"].extend(SYMPTOM_CONCEPT_RE.findall(line))
+ if not line.startswith(current["close"]):
+ continue
+ entry, current = current, None
+ if not entry["symptom"]:
+ continue
+ label, line_no, concepts = entry["label"], entry["line"], entry["concepts"]
+ if len(concepts) > 1:
+ report.error(
+ "symptom-concept-repeated", ONTOLOGY_PATH, line_no,
+ f"Symptom {label!r} has {len(concepts)} symptomConcept values; it is one symptom.",
+ )
+ continue
+ have = concepts[0] if concepts else None
+ if label not in expected:
+ report.warning(
+ "symptom-unmapped", ONTOLOGY_PATH, line_no,
+ f"Symptom {label!r} has no row in {SYMPTOM_MAPPING_PATH}"
+ + (f", so its symptomConcept {have} is left from a former label" if have else "")
+ + ". Add a row and run notebook/symptom-mapping/build_symptom_mapping.py.",
+ )
+ elif have == expected[label]:
+ continue
+ elif have is None:
+ report.warning(
+ "symptom-concept-missing", ONTOLOGY_PATH, line_no,
+ f"Symptom {label!r} maps to {expected[label]} in {SYMPTOM_MAPPING_PATH} but has no "
+ "symptomConcept. Run notebook/symptom-mapping/build_symptom_mapping.py.",
+ )
+ else:
+ report.error(
+ "symptom-concept-mismatch", ONTOLOGY_PATH, line_no,
+ f"Symptom {label!r} links {have}, but {SYMPTOM_MAPPING_PATH} maps it to "
+ f"{expected[label] or 'not a symptom'}. Run "
+ "notebook/symptom-mapping/build_symptom_mapping.py.",
+ )
+
+
def main() -> int:
parser = argparse.ArgumentParser(description=__doc__)
parser.add_argument(
@@ -1260,6 +1358,10 @@ def main() -> int:
check_against_ontology(sssom_rows, diseases, report)
check_equiv_against_ontology(equiv_rows, diseases, report)
check_ontology_values(diseases, report)
+ symptom_text = read_text(SYMPTOM_MAPPING_PATH, report)
+ if symptom_text:
+ symptom_rows = split_rows(symptom_text, SYMPTOM_MAPPING_PATH, SYMPTOM_MAPPING_COLUMNS, report)
+ check_symptom_concepts(current_text(ONTOLOGY_PATH), symptom_rows, report)
findings = sorted(report.findings, key=Finding.sort_key)
scope = "whole repository"
diff --git a/.github/workflows/mappings-validate.yml b/.github/workflows/mappings-validate.yml
index 42ccccc..f61155f 100644
--- a/.github/workflows/mappings-validate.yml
+++ b/.github/workflows/mappings-validate.yml
@@ -10,6 +10,7 @@ on:
paths:
- 'mappings/**'
- 'ontologies/**'
+ - 'notebook/symptom-mapping/symptom_mapping.tsv'
- '.github/scripts/validate_mappings.py'
- '.github/workflows/mappings-validate.yml'
diff --git a/changelog.md b/changelog.md
index 9dcb2a8..e30c218 100644
--- a/changelog.md
+++ b/changelog.md
@@ -1,5 +1,32 @@
# Changelog
+## claude/symptom-concept-links
+
+Links each per-disease Symptom individual to its shared symptom. "Fatigue" in 76 diseases can now
+be queried as one thing, and the 76 individuals stay separate. PR #148 kept same-label individuals
+apart on purpose, because each one holds its own disease's likelihood, description and source. The
+editor also destroys an individual when it is removed from a disease, so merging them would remove
+or edit the symptom for every disease at once.
+
+- New annotation property `symptomConcept` in `ontologies/ari_t1d.owl`. Its value is the IRI of
+ the `ARIS_…` class in `notebook/symptom-mapping/ari_symptoms.owl`. It is an annotation property
+ rather than an object property because the target is a class in another file.
+- `symptom_mapping.tsv` owns the link, keyed by the symptom string, and
+ `build_symptom_mapping.py` writes it. A merged string links the class it merges into. A `not a
+ symptom` string links nothing. The script edits only these lines and gives the same result on a
+ second run.
+- 2,248 of the 2,294 Symptom individuals are linked: all 2,242 live ones and 6
+ obsolete ones whose labels map. The other 46 are obsolete `not a symptom` entries.
+- `ari_symptoms.owl` no longer carries the reverse links (`ariSymptomIndividual`), so the link is
+ stored in one direction only.
+- `validate_mappings.py` checks each link against the TSV, and the PR gate now also runs when the
+ TSV changes. A link that disagrees with the TSV is an error. A symptom with no row, or a mapped
+ symptom with no link yet, is a warning, so adding a symptom in the editor doesn't block the publish.
+- Report 4's *Diseases (ontology)* counts are corrected for 50 symptoms. The old counts still
+ included individuals retired or merged in #143, #144, #148 and #149, whose PRs didn't rebuild the report.
+- Still to do in the editor (KrishnaTO/ARI-metadata-manager): set `symptomConcept` from the TSV
+ when a curator adds or renames a symptom. Until then, those symptoms show the warnings above
+ until the next build.
## claude/uberon-tissue-systems-linking-1f66a5
Links ARI's tissue and system classes to UBERON and imports the UBERON terms they link to.
diff --git a/data/4-reports/4_Additional_Info_Index.xlsx b/data/4-reports/4_Additional_Info_Index.xlsx
index 8e8d16a..2e714d7 100644
Binary files a/data/4-reports/4_Additional_Info_Index.xlsx and b/data/4-reports/4_Additional_Info_Index.xlsx differ
diff --git a/notebook/symptom-mapping/README.md b/notebook/symptom-mapping/README.md
index fde98d4..d4ada19 100644
--- a/notebook/symptom-mapping/README.md
+++ b/notebook/symptom-mapping/README.md
@@ -62,10 +62,29 @@ It then writes:
- **`ari_symptoms.owl`**: a class per exact or broader symptom (`ARIS_…`) under its parent. Each class has:
- `skos:exactMatch` or `skos:broadMatch` to its SYMP term and to its HPO term
- its merged strings as `skos:altLabel`
- - `ariSymptomIndividual` links to the Symptom individuals in `ari_t1d.owl` that carry it
The SYMP terms it references are copied in with their labels and is_a parents, up to *symptom*,
so the file opens in Protégé without importing SYMP. HPO terms are referenced by IRI only.
-The OWL file shows the proposal for review. `ontologies/ari_t1d.owl` is still the record, and it
-is not changed here.
+- **`symptomConcept` in `ontologies/ari_t1d.owl`**: on every Symptom individual, the `ARIS_…` class
+ its label maps to. A merged label links the class of the symptom it merges into; a `not a
+ symptom` label links nothing. Every other line of the ontology is left as it is.
+
+### Symptom individuals and shared symptoms
+
+A Symptom individual in `ari_t1d.owl` is one symptom *in one disease*: it carries that disease's
+likelihood, description and source, and the editor deletes it when a curator removes it from that
+disease. So "Fatigue" stays 76 individuals, one per disease, and each points at the one shared
+**Fatigue** class here with `symptomConcept`. To ask which diseases list fatigue:
+
+```sparql
+PREFIX ari:
+PREFIX aris:
+SELECT ?disease WHERE { ?disease ari:hasSymptom ?s . ?s ari:symptomConcept aris:ARIS_0000190 }
+```
+
+This table owns the link, keyed by the symptom string. The ontology only carries it.
+`.github/scripts/validate_mappings.py` checks every link against this table. A wrong link is an
+error. A symptom with no row yet, or a mapped symptom with no link yet, is a warning: it appears
+when a curator adds or renames a symptom in the editor. To clear it, add the row here and rerun
+the build.
diff --git a/notebook/symptom-mapping/ari_symptoms.owl b/notebook/symptom-mapping/ari_symptoms.owl
index 22feea2..773c292 100644
--- a/notebook/symptom-mapping/ari_symptoms.owl
+++ b/notebook/symptom-mapping/ari_symptoms.owl
@@ -9,7 +9,7 @@
xmlns="http://www.aurint.org/ontologies/ari-symptoms#">
- ARI symptoms grouped into a hierarchy and mapped to the Symptom Ontology (SYMP) and the Human Phenotype Ontology (HPO) for ARI#132, generated from notebook/symptom-mapping/symptom_mapping.tsv. skos:exactMatch names a SYMP or HPO term with the same meaning, skos:broadMatch the nearest broader one. Strings merged into a symptom are skos:altLabel. ariSymptomIndividual links the Symptom individuals in ontologies/ari_t1d.owl that carry the symptom. SYMP classes are copied with their labels and is_a parents only; HPO terms are referenced by IRI.
+ ARI symptoms grouped into a hierarchy and mapped to the Symptom Ontology (SYMP) and the Human Phenotype Ontology (HPO) for ARI#132, generated from notebook/symptom-mapping/symptom_mapping.tsv. skos:exactMatch names a SYMP or HPO term with the same meaning, skos:broadMatch the nearest broader one. Strings merged into a symptom are skos:altLabel. The Symptom individuals in ontologies/ari_t1d.owl point at their class with symptomConcept. SYMP classes are copied with their labels and is_a parents only; HPO terms are referenced by IRI.
@@ -18,9 +18,6 @@
-
- ARI symptom individual
-
abdominal cramp
@@ -1881,7 +1878,6 @@
ARIS:0000597
-
@@ -1890,7 +1886,6 @@
ARIS:0000001
-
@@ -1899,7 +1894,6 @@
ARIS:0000002
-
@@ -1908,11 +1902,6 @@
ARIS:0000003
-
-
-
-
-
@@ -1921,8 +1910,6 @@
ARIS:0000004
-
-
@@ -1931,32 +1918,6 @@
ARIS:0000005
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -1965,7 +1926,6 @@
ARIS:0000006
-
@@ -1974,7 +1934,6 @@
ARIS:0000007
-
@@ -1983,12 +1942,6 @@
ARIS:0000008
-
-
-
-
-
-
@@ -1997,7 +1950,6 @@
ARIS:0000009
-
@@ -2006,7 +1958,6 @@
ARIS:0000010
-
@@ -2015,7 +1966,6 @@
ARIS:0000598
-
@@ -2024,7 +1974,6 @@
ARIS:0000011
-
@@ -2033,7 +1982,6 @@
ARIS:0000012
-
@@ -2042,13 +1990,6 @@
ARIS:0000013
-
-
-
-
-
-
-
@@ -2057,7 +1998,6 @@
ARIS:0000599
-
@@ -2066,7 +2006,6 @@
ARIS:0000600
-
@@ -2075,7 +2014,6 @@
ARIS:0000601
-
@@ -2084,7 +2022,6 @@
ARIS:0000602
-
@@ -2093,7 +2030,6 @@
ARIS:0000014
-
@@ -2102,7 +2038,6 @@
ARIS:0000603
-
@@ -2111,9 +2046,6 @@
ARIS:0000015
-
-
-
@@ -2122,7 +2054,6 @@
ARIS:0000604
-
@@ -2131,7 +2062,6 @@
ARIS:0000605
-
@@ -2140,7 +2070,6 @@
ARIS:0000016
-
@@ -2149,7 +2078,6 @@
ARIS:0000606
-
@@ -2158,7 +2086,6 @@
ARIS:0000607
-
@@ -2167,7 +2094,6 @@
ARIS:0000017
-
@@ -2176,16 +2102,6 @@
ARIS:0000018
-
-
-
-
-
-
-
-
-
-
@@ -2194,7 +2110,6 @@
ARIS:0000019
-
@@ -2203,7 +2118,6 @@
ARIS:0000020
-
@@ -2212,7 +2126,6 @@
ARIS:0000021
-
@@ -2222,14 +2135,6 @@
Weakness in arms
-
-
-
-
-
-
-
-
@@ -2238,7 +2143,6 @@
ARIS:0000608
-
@@ -2247,7 +2151,6 @@
ARIS:0000609
-
@@ -2256,7 +2159,6 @@
ARIS:0000610
-
@@ -2265,7 +2167,6 @@
ARIS:0000023
-
@@ -2274,7 +2175,6 @@
ARIS:0000611
-
@@ -2283,7 +2183,6 @@
ARIS:0000024
-
@@ -2292,7 +2191,6 @@
ARIS:0000612
-
@@ -2301,7 +2199,6 @@
ARIS:0000613
-
@@ -2310,7 +2207,6 @@
ARIS:0000614
-
@@ -2319,7 +2215,6 @@
ARIS:0000615
-
@@ -2328,7 +2223,6 @@
ARIS:0000616
-
@@ -2337,7 +2231,6 @@
ARIS:0000025
-
@@ -2346,7 +2239,6 @@
ARIS:0000617
-
@@ -2355,16 +2247,6 @@
ARIS:0000026
-
-
-
-
-
-
-
-
-
-
@@ -2373,7 +2255,6 @@
ARIS:0000027
-
@@ -2382,7 +2263,6 @@
ARIS:0000028
-
@@ -2391,7 +2271,6 @@
ARIS:0000029
-
@@ -2400,7 +2279,6 @@
ARIS:0000030
-
@@ -2409,11 +2287,6 @@
ARIS:0000031
-
-
-
-
-
@@ -2422,7 +2295,6 @@
ARIS:0000032
-
@@ -2431,7 +2303,6 @@
ARIS:0000618
-
@@ -2440,7 +2311,6 @@
ARIS:0000619
-
@@ -2449,7 +2319,6 @@
ARIS:0000620
-
@@ -2458,7 +2327,6 @@
ARIS:0000621
-
@@ -2467,7 +2335,6 @@
ARIS:0000622
-
@@ -2476,7 +2343,6 @@
ARIS:0000033
-
@@ -2485,7 +2351,6 @@
ARIS:0000034
-
@@ -2494,8 +2359,6 @@
ARIS:0000035
-
-
@@ -2504,7 +2367,6 @@
ARIS:0000036
-
@@ -2513,8 +2375,6 @@
ARIS:0000037
-
-
@@ -2523,10 +2383,6 @@
ARIS:0000038
-
-
-
-
@@ -2535,10 +2391,6 @@
ARIS:0000039
-
-
-
-
@@ -2547,7 +2399,6 @@
ARIS:0000040
-
@@ -2556,7 +2407,6 @@
ARIS:0000041
-
@@ -2566,16 +2416,6 @@
Fluid-dilled sacs
-
-
-
-
-
-
-
-
-
-
@@ -2584,7 +2424,6 @@
ARIS:0000043
-
@@ -2593,7 +2432,6 @@
ARIS:0000044
-
@@ -2602,7 +2440,6 @@
ARIS:0000045
-
@@ -2612,9 +2449,6 @@
Skin blisters
-
-
-
@@ -2623,7 +2457,6 @@
ARIS:0000047
-
@@ -2632,7 +2465,6 @@
ARIS:0000048
-
@@ -2642,12 +2474,6 @@
Abdominal bloating
-
-
-
-
-
-
@@ -2656,7 +2482,6 @@
ARIS:0000050
-
@@ -2665,15 +2490,6 @@
ARIS:0000051
-
-
-
-
-
-
-
-
-
@@ -2682,13 +2498,6 @@
ARIS:0000052
-
-
-
-
-
-
-
@@ -2697,17 +2506,6 @@
ARIS:0000053
-
-
-
-
-
-
-
-
-
-
-
@@ -2716,27 +2514,6 @@
ARIS:0000054
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -2745,7 +2522,6 @@
ARIS:0000055
-
@@ -2754,10 +2530,6 @@
ARIS:0000056
-
-
-
-
@@ -2766,7 +2538,6 @@
ARIS:0000057
-
@@ -2775,8 +2546,6 @@
ARIS:0000058
-
-
@@ -2786,9 +2555,6 @@
Cognitive dysfunction ('brain fog')
-
-
-
@@ -2797,8 +2563,6 @@
ARIS:0000060
-
-
@@ -2807,7 +2571,6 @@
ARIS:0000623
-
@@ -2816,7 +2579,6 @@
ARIS:0000624
-
@@ -2826,8 +2588,6 @@
Forward displacement of eye
-
-
@@ -2836,7 +2596,6 @@
ARIS:0000062
-
@@ -2845,8 +2604,6 @@
ARIS:0000063
-
-
@@ -2855,7 +2612,6 @@
ARIS:0000064
-
@@ -2864,7 +2620,6 @@
ARIS:0000065
-
@@ -2874,25 +2629,6 @@
Burning
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -2901,7 +2637,6 @@
ARIS:0000067
-
@@ -2910,7 +2645,6 @@
ARIS:0000068
-
@@ -2919,7 +2653,6 @@
ARIS:0000069
-
@@ -2929,9 +2662,6 @@
Burning feeling when urinating
-
-
-
@@ -2940,8 +2670,6 @@
ARIS:0000071
-
-
@@ -2951,12 +2679,6 @@
Butterfly-shaped rash face that covers the cheeks and bridge of the nose
-
-
-
-
-
-
@@ -2965,7 +2687,6 @@
ARIS:0000073
-
@@ -2974,8 +2695,6 @@
ARIS:0000074
-
-
@@ -2984,7 +2703,6 @@
ARIS:0000075
-
@@ -2993,7 +2711,6 @@
ARIS:0000625
-
@@ -3002,7 +2719,6 @@
ARIS:0000076
-
@@ -3011,7 +2727,6 @@
ARIS:0000077
-
@@ -3020,7 +2735,6 @@
ARIS:0000078
-
@@ -3029,7 +2743,6 @@
ARIS:0000079
-
@@ -3038,7 +2751,6 @@
ARIS:0000080
-
@@ -3047,7 +2759,6 @@
ARIS:0000081
-
@@ -3056,7 +2767,6 @@
ARIS:0000082
-
@@ -3065,23 +2775,6 @@
ARIS:0000083
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -3090,13 +2783,6 @@
ARIS:0000084
-
-
-
-
-
-
-
@@ -3105,7 +2791,6 @@
ARIS:0000626
-
@@ -3114,7 +2799,6 @@
ARIS:0000627
-
@@ -3123,7 +2807,6 @@
ARIS:0000628
-
@@ -3133,8 +2816,6 @@
Massive hepatosplenomegaly and chronic lymphadenopathy
-
-
@@ -3143,7 +2824,6 @@
ARIS:0000629
-
@@ -3152,7 +2832,6 @@
ARIS:0000630
-
@@ -3161,7 +2840,6 @@
ARIS:0000631
-
@@ -3170,7 +2848,6 @@
ARIS:0000632
-
@@ -3179,7 +2856,6 @@
ARIS:0000633
-
@@ -3188,7 +2864,6 @@
ARIS:0000086
-
@@ -3197,7 +2872,6 @@
ARIS:0000087
-
@@ -3206,7 +2880,6 @@
ARIS:0000088
-
@@ -3215,7 +2888,6 @@
ARIS:0000634
-
@@ -3224,7 +2896,6 @@
ARIS:0000089
-
@@ -3233,12 +2904,6 @@
ARIS:0000090
-
-
-
-
-
-
@@ -3247,7 +2912,6 @@
ARIS:0000635
-
@@ -3256,7 +2920,6 @@
ARIS:0000091
-
@@ -3265,7 +2928,6 @@
ARIS:0000092
-
@@ -3275,10 +2937,6 @@
Sensitivity to extreme cold
-
-
-
-
@@ -3287,10 +2945,6 @@
ARIS:0000094
-
-
-
-
@@ -3299,7 +2953,6 @@
ARIS:0000095
-
@@ -3308,7 +2961,6 @@
ARIS:0000636
-
@@ -3317,8 +2969,6 @@
ARIS:0000096
-
-
@@ -3327,7 +2977,6 @@
ARIS:0000097
-
@@ -3336,7 +2985,6 @@
ARIS:0000637
-
@@ -3345,15 +2993,6 @@
ARIS:0000098
-
-
-
-
-
-
-
-
-
@@ -3362,7 +3001,6 @@
ARIS:0000099
-
@@ -3371,15 +3009,6 @@
ARIS:0000100
-
-
-
-
-
-
-
-
-
@@ -3388,7 +3017,6 @@
ARIS:0000101
-
@@ -3397,18 +3025,6 @@
ARIS:0000102
-
-
-
-
-
-
-
-
-
-
-
-
@@ -3418,8 +3034,6 @@
Spitting up blood
-
-
@@ -3428,7 +3042,6 @@
ARIS:0000638
-
@@ -3437,11 +3050,6 @@
ARIS:0000104
-
-
-
-
-
@@ -3450,7 +3058,6 @@
ARIS:0000639
-
@@ -3459,7 +3066,6 @@
ARIS:0000105
-
@@ -3468,7 +3074,6 @@
ARIS:0000106
-
@@ -3477,7 +3082,6 @@
ARIS:0000107
-
@@ -3486,8 +3090,6 @@
ARIS:0000108
-
-
@@ -3496,12 +3098,6 @@
ARIS:0000109
-
-
-
-
-
-
@@ -3510,7 +3106,6 @@
ARIS:0000110
-
@@ -3520,9 +3115,6 @@
Lack of sweat
-
-
-
@@ -3531,7 +3123,6 @@
ARIS:0000112
-
@@ -3540,7 +3131,6 @@
ARIS:0000113
-
@@ -3549,7 +3139,6 @@
ARIS:0000114
-
@@ -3559,8 +3148,6 @@
Stunted growth in children
-
-
@@ -3569,7 +3156,6 @@
ARIS:0000116
-
@@ -3578,8 +3164,6 @@
ARIS:0000117
-
-
@@ -3588,7 +3172,6 @@
ARIS:0000118
-
@@ -3597,17 +3180,6 @@
ARIS:0000119
-
-
-
-
-
-
-
-
-
-
-
@@ -3616,7 +3188,6 @@
ARIS:0000120
-
@@ -3625,7 +3196,6 @@
ARIS:0000121
-
@@ -3634,7 +3204,6 @@
ARIS:0000640
-
@@ -3643,7 +3212,6 @@
ARIS:0000122
-
@@ -3652,28 +3220,6 @@
ARIS:0000123
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -3682,7 +3228,6 @@
ARIS:0000124
-
@@ -3691,7 +3236,6 @@
ARIS:0000125
-
@@ -3700,9 +3244,6 @@
ARIS:0000126
-
-
-
@@ -3711,9 +3252,6 @@
ARIS:0000127
-
-
-
@@ -3723,11 +3261,6 @@
Concentration loss
-
-
-
-
-
@@ -3736,7 +3269,6 @@
ARIS:0000129
-
@@ -3745,7 +3277,6 @@
ARIS:0000130
-
@@ -3754,7 +3285,6 @@
ARIS:0000131
-
@@ -3764,8 +3294,6 @@
Trouble rising from a chair
-
-
@@ -3774,7 +3302,6 @@
ARIS:0000133
-
@@ -3784,8 +3311,6 @@
Impaired color vision / dyschromatopsia
-
-
@@ -3794,16 +3319,6 @@
ARIS:0000135
-
-
-
-
-
-
-
-
-
-
@@ -3812,22 +3327,6 @@
ARIS:0000136
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -3836,7 +3335,6 @@
ARIS:0000137
-
@@ -3845,7 +3343,6 @@
ARIS:0000138
-
@@ -3854,8 +3351,6 @@
ARIS:0000139
-
-
@@ -3864,7 +3359,6 @@
ARIS:0000140
-
@@ -3873,7 +3367,6 @@
ARIS:0000641
-
@@ -3882,7 +3375,6 @@
ARIS:0000642
-
@@ -3891,7 +3383,6 @@
ARIS:0000643
-
@@ -3902,9 +3393,6 @@
Discomfort in legs that is relieved by movement
Discomfort in legs that occur mainly at night
-
-
-
@@ -3913,7 +3401,6 @@
ARIS:0000142
-
@@ -3922,7 +3409,6 @@
ARIS:0000143
-
@@ -3931,8 +3417,6 @@
ARIS:0000144
-
-
@@ -3941,7 +3425,6 @@
ARIS:0000644
-
@@ -3950,7 +3433,6 @@
ARIS:0000645
-
@@ -3959,7 +3441,6 @@
ARIS:0000646
-
@@ -3968,7 +3449,6 @@
ARIS:0000647
-
@@ -3977,7 +3457,6 @@
ARIS:0000648
-
@@ -3986,7 +3465,6 @@
ARIS:0000145
-
@@ -3994,25 +3472,6 @@
Dizziness
ARIS:0000146
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -4021,17 +3480,6 @@
ARIS:0000147
-
-
-
-
-
-
-
-
-
-
-
@@ -4040,10 +3488,6 @@
ARIS:0000148
-
-
-
-
@@ -4053,11 +3497,6 @@
Daytime sleepiness
-
-
-
-
-
@@ -4066,8 +3505,6 @@
ARIS:0000150
-
-
@@ -4076,15 +3513,6 @@
ARIS:0000151
-
-
-
-
-
-
-
-
-
@@ -4093,11 +3521,6 @@
ARIS:0000152
-
-
-
-
-
@@ -4106,8 +3529,6 @@
ARIS:0000153
-
-
@@ -4116,7 +3537,6 @@
ARIS:0000154
-
@@ -4125,7 +3545,6 @@
ARIS:0000155
-
@@ -4134,7 +3553,6 @@
ARIS:0000156
-
@@ -4143,8 +3561,6 @@
ARIS:0000157
-
-
@@ -4153,7 +3569,6 @@
ARIS:0000158
-
@@ -4162,7 +3577,6 @@
ARIS:0000649
-
@@ -4171,7 +3585,6 @@
ARIS:0000159
-
@@ -4180,7 +3593,6 @@
ARIS:0000650
-
@@ -4189,7 +3601,6 @@
ARIS:0000160
-
@@ -4198,7 +3609,6 @@
ARIS:0000651
-
@@ -4207,15 +3617,6 @@
ARIS:0000161
-
-
-
-
-
-
-
-
-
@@ -4224,7 +3625,6 @@
ARIS:0000162
-
@@ -4233,7 +3633,6 @@
ARIS:0000163
-
@@ -4242,7 +3641,6 @@
ARIS:0000164
-
@@ -4251,7 +3649,6 @@
ARIS:0000165
-
@@ -4260,7 +3657,6 @@
ARIS:0000166
-
@@ -4269,7 +3665,6 @@
ARIS:0000167
-
@@ -4279,8 +3674,6 @@
Epilepsy
-
-
@@ -4289,9 +3682,6 @@
ARIS:0000169
-
-
-
@@ -4300,7 +3690,6 @@
ARIS:0000652
-
@@ -4309,7 +3698,6 @@
ARIS:0000170
-
@@ -4318,7 +3706,6 @@
ARIS:0000171
-
@@ -4328,9 +3715,6 @@
An increase in perspiration or warm, moist skin
-
-
-
@@ -4339,7 +3723,6 @@
ARIS:0000653
-
@@ -4348,7 +3731,6 @@
ARIS:0000654
-
@@ -4357,7 +3739,6 @@
ARIS:0000655
-
@@ -4366,7 +3747,6 @@
ARIS:0000656
-
@@ -4375,8 +3755,6 @@
ARIS:0000173
-
-
@@ -4385,12 +3763,6 @@
ARIS:0000174
-
-
-
-
-
-
@@ -4399,12 +3771,6 @@
ARIS:0000175
-
-
-
-
-
-
@@ -4413,7 +3779,6 @@
ARIS:0000176
-
@@ -4422,21 +3787,6 @@
ARIS:0000177
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -4445,7 +3795,6 @@
ARIS:0000178
-
@@ -4454,7 +3803,6 @@
ARIS:0000179
-
@@ -4463,12 +3811,6 @@
ARIS:0000180
-
-
-
-
-
-
@@ -4477,7 +3819,6 @@
ARIS:0000181
-
@@ -4487,8 +3828,6 @@
Facial reddening
-
-
@@ -4497,9 +3836,6 @@
ARIS:0000183
-
-
-
@@ -4508,7 +3844,6 @@
ARIS:0000184
-
@@ -4517,8 +3852,6 @@
ARIS:0000185
-
-
@@ -4527,8 +3860,6 @@
ARIS:0000186
-
-
@@ -4537,8 +3868,6 @@
ARIS:0000187
-
-
@@ -4547,7 +3876,6 @@
ARIS:0000188
-
@@ -4556,8 +3884,6 @@
ARIS:0000189
-
-
@@ -4566,82 +3892,6 @@
ARIS:0000190
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -4650,7 +3900,6 @@
ARIS:0000191
-
@@ -4659,8 +3908,6 @@
ARIS:0000192
-
-
@@ -4669,8 +3916,6 @@
ARIS:0000193
-
-
@@ -4679,7 +3924,6 @@
ARIS:0000194
-
@@ -4688,7 +3932,6 @@
ARIS:0000195
-
@@ -4697,51 +3940,6 @@
ARIS:0000196
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -4750,8 +3948,6 @@
ARIS:0000197
-
-
@@ -4760,7 +3956,6 @@
ARIS:0000198
-
@@ -4769,7 +3964,6 @@
ARIS:0000199
-
@@ -4778,7 +3972,6 @@
ARIS:0000200
-
@@ -4787,7 +3980,6 @@
ARIS:0000201
-
@@ -4796,9 +3988,6 @@
ARIS:0000202
-
-
-
@@ -4808,9 +3997,6 @@
Flu-like prodrome
-
-
-
@@ -4819,7 +4005,6 @@
ARIS:0000204
-
@@ -4828,8 +4013,6 @@
ARIS:0000205
-
-
@@ -4838,7 +4021,6 @@
ARIS:0000657
-
@@ -4847,7 +4029,6 @@
ARIS:0000206
-
@@ -4856,14 +4037,6 @@
ARIS:0000207
-
-
-
-
-
-
-
-
@@ -4872,7 +4045,6 @@
ARIS:0000208
-
@@ -4881,7 +4053,6 @@
ARIS:0000209
-
@@ -4890,7 +4061,6 @@
ARIS:0000210
-
@@ -4899,7 +4069,6 @@
ARIS:0000211
-
@@ -4908,7 +4077,6 @@
ARIS:0000212
-
@@ -4917,7 +4085,6 @@
ARIS:0000213
-
@@ -4926,7 +4093,6 @@
ARIS:0000658
-
@@ -4935,7 +4101,6 @@
ARIS:0000214
-
@@ -4944,7 +4109,6 @@
ARIS:0000215
-
@@ -4954,8 +4118,6 @@
Gottron's papules / sign
-
-
@@ -4964,7 +4126,6 @@
ARIS:0000216
-
@@ -4973,7 +4134,6 @@
ARIS:0000217
-
@@ -4983,15 +4143,6 @@
Alopecia
-
-
-
-
-
-
-
-
-
@@ -5000,9 +4151,6 @@
ARIS:0000219
-
-
-
@@ -5011,13 +4159,6 @@
ARIS:0000220
-
-
-
-
-
-
-
@@ -5026,7 +4167,6 @@
ARIS:0000221
-
@@ -5035,8 +4175,6 @@
ARIS:0000222
-
-
@@ -5045,7 +4183,6 @@
ARIS:0000223
-
@@ -5054,7 +4191,6 @@
ARIS:0000660
-
@@ -5063,33 +4199,6 @@
ARIS:0000224
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -5099,14 +4208,6 @@
Loss of hearing
-
-
-
-
-
-
-
-
@@ -5115,7 +4216,6 @@
ARIS:0000226
-
@@ -5124,8 +4224,6 @@
ARIS:0000227
-
-
@@ -5134,10 +4232,6 @@
ARIS:0000228
-
-
-
-
@@ -5146,7 +4240,6 @@
ARIS:0000229
-
@@ -5156,13 +4249,6 @@
Prolonged menstrual bleeding
-
-
-
-
-
-
-
@@ -5171,7 +4257,6 @@
ARIS:0000661
-
@@ -5180,7 +4265,6 @@
ARIS:0000231
-
@@ -5189,8 +4273,6 @@
ARIS:0000232
-
-
@@ -5199,7 +4281,6 @@
ARIS:0000233
-
@@ -5208,8 +4289,6 @@
ARIS:0000234
-
-
@@ -5218,7 +4297,6 @@
ARIS:0000662
-
@@ -5227,7 +4305,6 @@
ARIS:0000235
-
@@ -5236,7 +4313,6 @@
ARIS:0000236
-
@@ -5245,9 +4321,6 @@
ARIS:0000237
-
-
-
@@ -5256,8 +4329,6 @@
ARIS:0000238
-
-
@@ -5267,12 +4338,6 @@
Red or skin colored welts, can vary in size, shape and appear anywhere on the body
-
-
-
-
-
-
@@ -5281,8 +4346,6 @@
ARIS:0000240
-
-
@@ -5291,7 +4354,6 @@
ARIS:0000241
-
@@ -5300,9 +4362,6 @@
ARIS:0000242
-
-
-
@@ -5311,7 +4370,6 @@
ARIS:0000663
-
@@ -5320,7 +4378,6 @@
ARIS:0000664
-
@@ -5329,9 +4386,6 @@
ARIS:0000243
-
-
-
@@ -5340,7 +4394,6 @@
ARIS:0000244
-
@@ -5349,7 +4402,6 @@
ARIS:0000665
-
@@ -5359,8 +4411,6 @@
Hypogammaglobulinemia with recurrent sinopulmonary bacterial infections
-
-
@@ -5369,7 +4419,6 @@
ARIS:0000667
-
@@ -5378,7 +4427,6 @@
ARIS:0000668
-
@@ -5387,7 +4435,6 @@
ARIS:0000669
-
@@ -5396,7 +4443,6 @@
ARIS:0000670
-
@@ -5405,7 +4451,6 @@
ARIS:0000671
-
@@ -5414,10 +4459,6 @@
ARIS:0000245
-
-
-
-
@@ -5426,7 +4467,6 @@
ARIS:0000246
-
@@ -5435,7 +4475,6 @@
ARIS:0000247
-
@@ -5444,7 +4483,6 @@
ARIS:0000248
-
@@ -5453,10 +4491,6 @@
ARIS:0000249
-
-
-
-
@@ -5465,8 +4499,6 @@
ARIS:0000250
-
-
@@ -5478,13 +4510,6 @@
Inability to conceive after ≥1 year of unprotected intercourse with normal evaluations
Unable to conceive
Unexplained primary or secondary infertility despite regular intercourse
-
-
-
-
-
-
-
@@ -5493,7 +4518,6 @@
ARIS:0000252
-
@@ -5502,7 +4526,6 @@
ARIS:0000672
-
@@ -5511,7 +4534,6 @@
ARIS:0000673
-
@@ -5520,7 +4542,6 @@
ARIS:0000253
-
@@ -5529,11 +4550,6 @@
ARIS:0000254
-
-
-
-
-
@@ -5542,7 +4558,6 @@
ARIS:0000674
-
@@ -5551,15 +4566,6 @@
ARIS:0000255
-
-
-
-
-
-
-
-
-
@@ -5568,16 +4574,6 @@
ARIS:0000256
-
-
-
-
-
-
-
-
-
-
@@ -5586,7 +4582,6 @@
ARIS:0000257
-
@@ -5595,7 +4590,6 @@
ARIS:0000258
-
@@ -5605,14 +4599,6 @@
Itchy skin
-
-
-
-
-
-
-
-
@@ -5621,7 +4607,6 @@
ARIS:0000260
-
@@ -5630,7 +4615,6 @@
ARIS:0000261
-
@@ -5639,7 +4623,6 @@
ARIS:0000262
-
@@ -5648,48 +4631,6 @@
ARIS:0000263
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -5698,14 +4639,6 @@
ARIS:0000264
-
-
-
-
-
-
-
-
@@ -5714,8 +4647,6 @@
ARIS:0000265
-
-
@@ -5724,8 +4655,6 @@
ARIS:0000266
-
-
@@ -5734,7 +4663,6 @@
ARIS:0000267
-
@@ -5743,7 +4671,6 @@
ARIS:0000268
-
@@ -5752,7 +4679,6 @@
ARIS:0000269
-
@@ -5761,7 +4687,6 @@
ARIS:0000270
-
@@ -5770,7 +4695,6 @@
ARIS:0000675
-
@@ -5779,7 +4703,6 @@
ARIS:0000676
-
@@ -5788,7 +4711,6 @@
ARIS:0000271
-
@@ -5797,7 +4719,6 @@
ARIS:0000272
-
@@ -5806,9 +4727,6 @@
ARIS:0000273
-
-
-
@@ -5817,7 +4735,6 @@
ARIS:0000274
-
@@ -5826,8 +4743,6 @@
ARIS:0000275
-
-
@@ -5836,10 +4751,6 @@
ARIS:0000276
-
-
-
-
@@ -5848,7 +4759,6 @@
ARIS:0000677
-
@@ -5858,8 +4768,6 @@
Restricted mobility
-
-
@@ -5868,7 +4776,6 @@
ARIS:0000278
-
@@ -5877,7 +4784,6 @@
ARIS:0000279
-
@@ -5886,7 +4792,6 @@
ARIS:0000280
-
@@ -5895,7 +4800,6 @@
ARIS:0000678
-
@@ -5904,8 +4808,6 @@
ARIS:0000281
-
-
@@ -5914,7 +4816,6 @@
ARIS:0000282
-
@@ -5923,10 +4824,6 @@
ARIS:0000283
-
-
-
-
@@ -5935,7 +4832,6 @@
ARIS:0000284
-
@@ -5944,7 +4840,6 @@
ARIS:0000285
-
@@ -5954,8 +4849,6 @@
Absence of eyelashes
-
-
@@ -5964,7 +4857,6 @@
ARIS:0000287
-
@@ -5973,8 +4865,6 @@
ARIS:0000288
-
-
@@ -5983,7 +4873,6 @@
ARIS:0000289
-
@@ -5992,7 +4881,6 @@
ARIS:0000290
-
@@ -6001,7 +4889,6 @@
ARIS:0000291
-
@@ -6010,7 +4897,6 @@
ARIS:0000292
-
@@ -6020,12 +4906,6 @@
Sensory impairment
-
-
-
-
-
-
@@ -6034,7 +4914,6 @@
ARIS:0000294
-
@@ -6043,7 +4922,6 @@
ARIS:0000295
-
@@ -6068,7 +4946,6 @@
ARIS:0000298
-
@@ -6077,8 +4954,6 @@
ARIS:0000299
-
-
@@ -6087,7 +4962,6 @@
ARIS:0000300
-
@@ -6096,8 +4970,6 @@
ARIS:0000679
-
-
@@ -6106,12 +4978,6 @@
ARIS:0000301
-
-
-
-
-
-
@@ -6120,7 +4986,6 @@
ARIS:0000680
-
@@ -6129,7 +4994,6 @@
ARIS:0000302
-
@@ -6138,7 +5002,6 @@
ARIS:0000681
-
@@ -6147,7 +5010,6 @@
ARIS:0000303
-
@@ -6157,16 +5019,6 @@
Difficulty retaining information
-
-
-
-
-
-
-
-
-
-
@@ -6175,7 +5027,6 @@
ARIS:0000305
-
@@ -6184,7 +5035,6 @@
ARIS:0000306
-
@@ -6193,7 +5043,6 @@
ARIS:0000307
-
@@ -6203,8 +5052,6 @@
Microangiopathic hemolytic anemia with fragmented schistocytes
-
-
@@ -6213,9 +5060,6 @@
ARIS:0000309
-
-
-
@@ -6224,7 +5068,6 @@
ARIS:0000310
-
@@ -6233,7 +5076,6 @@
ARIS:0000682
-
@@ -6242,7 +5084,6 @@
ARIS:0000311
-
@@ -6251,7 +5092,6 @@
ARIS:0000312
-
@@ -6260,7 +5100,6 @@
ARIS:0000313
-
@@ -6269,8 +5108,6 @@
ARIS:0000314
-
-
@@ -6279,10 +5116,6 @@
ARIS:0000315
-
-
-
-
@@ -6291,7 +5124,6 @@
ARIS:0000316
-
@@ -6301,17 +5133,6 @@
Mouth ulcers
-
-
-
-
-
-
-
-
-
-
-
@@ -6320,7 +5141,6 @@
ARIS:0000318
-
@@ -6329,7 +5149,6 @@
ARIS:0000683
-
@@ -6338,7 +5157,6 @@
ARIS:0000319
-
@@ -6347,7 +5165,6 @@
ARIS:0000684
-
@@ -6356,7 +5173,6 @@
ARIS:0000320
-
@@ -6365,8 +5181,6 @@
ARIS:0000321
-
-
@@ -6376,8 +5190,6 @@
Peripheral nerve hyperexcitability (myokymia, fasciculations, muscle cramps)
-
-
@@ -6386,7 +5198,6 @@
ARIS:0000322
-
@@ -6395,33 +5206,6 @@
ARIS:0000323
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -6430,7 +5214,6 @@
ARIS:0000324
-
@@ -6439,13 +5222,6 @@
ARIS:0000325
-
-
-
-
-
-
-
@@ -6454,8 +5230,6 @@
ARIS:0000326
-
-
@@ -6464,8 +5238,6 @@
ARIS:0000327
-
-
@@ -6474,7 +5246,6 @@
ARIS:0000328
-
@@ -6483,7 +5254,6 @@
ARIS:0000329
-
@@ -6492,9 +5262,6 @@
ARIS:0000330
-
-
-
@@ -6503,33 +5270,6 @@
ARIS:0000331
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -6538,7 +5278,6 @@
ARIS:0000332
-
@@ -6547,7 +5286,6 @@
ARIS:0000333
-
@@ -6556,7 +5294,6 @@
ARIS:0000686
-
@@ -6565,12 +5302,6 @@
ARIS:0000334
-
-
-
-
-
-
@@ -6580,8 +5311,6 @@
Increased urination at night
-
-
@@ -6590,7 +5319,6 @@
ARIS:0000336
-
@@ -6599,7 +5327,6 @@
ARIS:0000337
-
@@ -6608,7 +5335,6 @@
ARIS:0000338
-
@@ -6617,7 +5343,6 @@
ARIS:0000339
-
@@ -6626,7 +5351,6 @@
ARIS:0000340
-
@@ -6635,7 +5359,6 @@
ARIS:0000341
-
@@ -6644,12 +5367,6 @@
ARIS:0000342
-
-
-
-
-
-
@@ -6658,15 +5375,6 @@
ARIS:0000343
-
-
-
-
-
-
-
-
-
@@ -6675,7 +5383,6 @@
ARIS:0000344
-
@@ -6684,7 +5391,6 @@
ARIS:0000687
-
@@ -6693,7 +5399,6 @@
ARIS:0000688
-
@@ -6702,7 +5407,6 @@
ARIS:0000345
-
@@ -6711,7 +5415,6 @@
ARIS:0000346
-
@@ -6720,7 +5423,6 @@
ARIS:0000689
-
@@ -6729,7 +5431,6 @@
ARIS:0000347
-
@@ -6738,7 +5439,6 @@
ARIS:0000348
-
@@ -6747,7 +5447,6 @@
ARIS:0000349
-
@@ -6756,108 +5455,6 @@
ARIS:0000350
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -6866,7 +5463,6 @@
ARIS:0000351
-
@@ -6875,7 +5471,6 @@
ARIS:0000352
-
@@ -6884,7 +5479,6 @@
ARIS:0000353
-
@@ -6893,9 +5487,6 @@
ARIS:0000354
-
-
-
@@ -6905,9 +5496,6 @@
Pain when urinating
-
-
-
@@ -6916,7 +5504,6 @@
ARIS:0000356
-
@@ -6925,7 +5512,6 @@
ARIS:0000357
-
@@ -6934,7 +5520,6 @@
ARIS:0000358
-
@@ -6944,9 +5529,6 @@
Tendon pain
-
-
-
@@ -6955,7 +5537,6 @@
ARIS:0000360
-
@@ -6964,7 +5545,6 @@
ARIS:0000361
-
@@ -6973,7 +5553,6 @@
ARIS:0000362
-
@@ -6982,7 +5561,6 @@
ARIS:0000363
-
@@ -6991,7 +5569,6 @@
ARIS:0000364
-
@@ -7000,7 +5577,6 @@
ARIS:0000365
-
@@ -7009,7 +5585,6 @@
ARIS:0000366
-
@@ -7018,7 +5593,6 @@
ARIS:0000367
-
@@ -7027,7 +5601,6 @@
ARIS:0000368
-
@@ -7036,7 +5609,6 @@
ARIS:0000690
-
@@ -7045,7 +5617,6 @@
ARIS:0000369
-
@@ -7054,7 +5625,6 @@
ARIS:0000691
-
@@ -7063,7 +5633,6 @@
ARIS:0000370
-
@@ -7072,7 +5641,6 @@
ARIS:0000371
-
@@ -7081,7 +5649,6 @@
ARIS:0000372
-
@@ -7090,7 +5657,6 @@
ARIS:0000373
-
@@ -7099,7 +5665,6 @@
ARIS:0000374
-
@@ -7108,7 +5673,6 @@
ARIS:0000375
-
@@ -7117,7 +5681,6 @@
ARIS:0000376
-
@@ -7126,7 +5689,6 @@
ARIS:0000692
-
@@ -7135,7 +5697,6 @@
ARIS:0000693
-
@@ -7144,9 +5705,6 @@
ARIS:0000377
-
-
-
@@ -7155,7 +5713,6 @@
ARIS:0000694
-
@@ -7164,7 +5721,6 @@
ARIS:0000695
-
@@ -7173,7 +5729,6 @@
ARIS:0000696
-
@@ -7182,7 +5737,6 @@
ARIS:0000378
-
@@ -7191,10 +5745,6 @@
ARIS:0000379
-
-
-
-
@@ -7204,8 +5754,6 @@
Inability to move the eye
-
-
@@ -7214,7 +5762,6 @@
ARIS:0000381
-
@@ -7223,8 +5770,6 @@
ARIS:0000382
-
-
@@ -7233,7 +5778,6 @@
ARIS:0000383
-
@@ -7242,8 +5786,6 @@
ARIS:0000384
-
-
@@ -7252,7 +5794,6 @@
ARIS:0000697
-
@@ -7261,7 +5802,6 @@
ARIS:0000385
-
@@ -7270,7 +5810,6 @@
ARIS:0000386
-
@@ -7279,7 +5818,6 @@
ARIS:0000387
-
@@ -7288,7 +5826,6 @@
ARIS:0000698
-
@@ -7297,7 +5834,6 @@
ARIS:0000699
-
@@ -7306,7 +5842,6 @@
ARIS:0000700
-
@@ -7315,9 +5850,6 @@
ARIS:0000388
-
-
-
@@ -7326,7 +5858,6 @@
ARIS:0000701
-
@@ -7336,11 +5867,6 @@
Increased thirst
-
-
-
-
-
@@ -7349,7 +5875,6 @@
ARIS:0000702
-
@@ -7359,8 +5884,6 @@
Increased urination
-
-
@@ -7369,7 +5892,6 @@
ARIS:0000391
-
@@ -7378,7 +5900,6 @@
ARIS:0000392
-
@@ -7387,7 +5908,6 @@
ARIS:0000393
-
@@ -7396,7 +5916,6 @@
ARIS:0000394
-
@@ -7405,7 +5924,6 @@
ARIS:0000703
-
@@ -7414,7 +5932,6 @@
ARIS:0000395
-
@@ -7423,7 +5940,6 @@
ARIS:0000704
-
@@ -7432,7 +5948,6 @@
ARIS:0000396
-
@@ -7441,7 +5956,6 @@
ARIS:0000705
-
@@ -7450,7 +5964,6 @@
ARIS:0000397
-
@@ -7460,8 +5973,6 @@
Progressive exertional dyspnea and exercise limitation
-
-
@@ -7470,7 +5981,6 @@
ARIS:0000707
-
@@ -7479,7 +5989,6 @@
ARIS:0000708
-
@@ -7488,7 +5997,6 @@
ARIS:0000398
-
@@ -7497,7 +6005,6 @@
ARIS:0000399
-
@@ -7506,7 +6013,6 @@
ARIS:0000400
-
@@ -7515,7 +6021,6 @@
ARIS:0000401
-
@@ -7524,7 +6029,6 @@
ARIS:0000402
-
@@ -7533,8 +6037,6 @@
ARIS:0000403
-
-
@@ -7543,7 +6045,6 @@
ARIS:0000404
-
@@ -7552,7 +6053,6 @@
ARIS:0000709
-
@@ -7561,7 +6061,6 @@
ARIS:0000405
-
@@ -7570,7 +6069,6 @@
ARIS:0000710
-
@@ -7579,7 +6077,6 @@
ARIS:0000711
-
@@ -7588,7 +6085,6 @@
ARIS:0000406
-
@@ -7597,7 +6093,6 @@
ARIS:0000712
-
@@ -7606,10 +6101,6 @@
ARIS:0000407
-
-
-
-
@@ -7618,7 +6109,6 @@
ARIS:0000408
-
@@ -7627,7 +6117,6 @@
ARIS:0000409
-
@@ -7636,7 +6125,6 @@
ARIS:0000410
-
@@ -7645,7 +6133,6 @@
ARIS:0000411
-
@@ -7654,7 +6141,6 @@
ARIS:0000713
-
@@ -7663,7 +6149,6 @@
ARIS:0000412
-
@@ -7672,7 +6157,6 @@
ARIS:0000413
-
@@ -7681,7 +6165,6 @@
ARIS:0000414
-
@@ -7690,7 +6173,6 @@
ARIS:0000714
-
@@ -7699,16 +6181,6 @@
ARIS:0000415
-
-
-
-
-
-
-
-
-
-
@@ -7717,7 +6189,6 @@
ARIS:0000715
-
@@ -7726,7 +6197,6 @@
ARIS:0000716
-
@@ -7735,7 +6205,6 @@
ARIS:0000717
-
@@ -7744,7 +6213,6 @@
ARIS:0000416
-
@@ -7753,7 +6221,6 @@
ARIS:0000718
-
@@ -7762,33 +6229,6 @@
ARIS:0000417
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -7797,7 +6237,6 @@
ARIS:0000418
-
@@ -7806,7 +6245,6 @@
ARIS:0000419
-
@@ -7815,7 +6253,6 @@
ARIS:0000420
-
@@ -7824,7 +6261,6 @@
ARIS:0000719
-
@@ -7833,7 +6269,6 @@
ARIS:0000421
-
@@ -7842,7 +6277,6 @@
ARIS:0000422
-
@@ -7851,7 +6285,6 @@
ARIS:0000720
-
@@ -7860,7 +6293,6 @@
ARIS:0000721
-
@@ -7869,7 +6301,6 @@
ARIS:0000423
-
@@ -7878,7 +6309,6 @@
ARIS:0000722
-
@@ -7889,14 +6319,6 @@
Frequent infections
Prone to infections
-
-
-
-
-
-
-
-
@@ -7905,7 +6327,6 @@
ARIS:0000425
-
@@ -7914,7 +6335,6 @@
ARIS:0000723
-
@@ -7923,7 +6343,6 @@
ARIS:0000426
-
@@ -7932,14 +6351,6 @@
ARIS:0000427
-
-
-
-
-
-
-
-
@@ -7948,7 +6359,6 @@
ARIS:0000428
-
@@ -7957,7 +6367,6 @@
ARIS:0000429
-
@@ -7966,7 +6375,6 @@
ARIS:0000430
-
@@ -7975,7 +6383,6 @@
ARIS:0000431
-
@@ -7984,10 +6391,6 @@
ARIS:0000432
-
-
-
-
@@ -7996,7 +6399,6 @@
ARIS:0000433
-
@@ -8005,7 +6407,6 @@
ARIS:0000434
-
@@ -8014,9 +6415,6 @@
ARIS:0000435
-
-
-
@@ -8025,7 +6423,6 @@
ARIS:0000724
-
@@ -8034,7 +6431,6 @@
ARIS:0000725
-
@@ -8043,7 +6439,6 @@
ARIS:0000726
-
@@ -8052,7 +6447,6 @@
ARIS:0000436
-
@@ -8061,7 +6455,6 @@
ARIS:0000727
-
@@ -8070,7 +6463,6 @@
ARIS:0000437
-
@@ -8079,7 +6471,6 @@
ARIS:0000438
-
@@ -8088,7 +6479,6 @@
ARIS:0000728
-
@@ -8097,7 +6487,6 @@
ARIS:0000729
-
@@ -8106,7 +6495,6 @@
ARIS:0000439
-
@@ -8115,7 +6503,6 @@
ARIS:0000440
-
@@ -8125,11 +6512,6 @@
Ringing in the ear
-
-
-
-
-
@@ -8138,7 +6520,6 @@
ARIS:0000442
-
@@ -8147,7 +6528,6 @@
ARIS:0000443
-
@@ -8156,7 +6536,6 @@
ARIS:0000444
-
@@ -8165,7 +6544,6 @@
ARIS:0000445
-
@@ -8174,7 +6552,6 @@
ARIS:0000446
-
@@ -8183,7 +6560,6 @@
ARIS:0000447
-
@@ -8192,7 +6568,6 @@
ARIS:0000448
-
@@ -8201,8 +6576,6 @@
ARIS:0000449
-
-
@@ -8211,7 +6584,6 @@
ARIS:0000450
-
@@ -8221,8 +6593,6 @@
Apparent flashes of light
-
-
@@ -8231,7 +6601,6 @@
ARIS:0000452
-
@@ -8240,7 +6609,6 @@
ARIS:0000453
-
@@ -8249,21 +6617,6 @@
ARIS:0000454
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -8272,8 +6625,6 @@
ARIS:0000455
-
-
@@ -8282,7 +6633,6 @@
ARIS:0000456
-
@@ -8291,19 +6641,6 @@
ARIS:0000457
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -8312,7 +6649,6 @@
ARIS:0000458
-
@@ -8321,7 +6657,6 @@
ARIS:0000730
-
@@ -8330,7 +6665,6 @@
ARIS:0000459
-
@@ -8339,7 +6673,6 @@
ARIS:0000731
-
@@ -8348,7 +6681,6 @@
ARIS:0000732
-
@@ -8357,7 +6689,6 @@
ARIS:0000460
-
@@ -8366,7 +6697,6 @@
ARIS:0000733
-
@@ -8375,7 +6705,6 @@
ARIS:0000734
-
@@ -8385,8 +6714,6 @@
Severe neck flexor weakness and prominent dysphagia
-
-
@@ -8395,7 +6722,6 @@
ARIS:0000736
-
@@ -8404,7 +6730,6 @@
ARIS:0000737
-
@@ -8413,7 +6738,6 @@
ARIS:0000738
-
@@ -8422,8 +6746,6 @@
ARIS:0000461
-
-
@@ -8432,7 +6754,6 @@
ARIS:0000462
-
@@ -8441,7 +6762,6 @@
ARIS:0000739
-
@@ -8450,7 +6770,6 @@
ARIS:0000740
-
@@ -8459,7 +6778,6 @@
ARIS:0000463
-
@@ -8469,8 +6787,6 @@
Symmetrical proximal muscle weakness
-
-
@@ -8479,7 +6795,6 @@
ARIS:0000742
-
@@ -8488,7 +6803,6 @@
ARIS:0000464
-
@@ -8497,7 +6811,6 @@
ARIS:0000465
-
@@ -8506,7 +6819,6 @@
ARIS:0000466
-
@@ -8515,7 +6827,6 @@
ARIS:0000743
-
@@ -8524,7 +6835,6 @@
ARIS:0000744
-
@@ -8533,7 +6843,6 @@
ARIS:0000467
-
@@ -8542,7 +6851,6 @@
ARIS:0000745
-
@@ -8551,7 +6859,6 @@
ARIS:0000746
-
@@ -8560,7 +6867,6 @@
ARIS:0000747
-
@@ -8569,7 +6875,6 @@
ARIS:0000468
-
@@ -8578,7 +6883,6 @@
ARIS:0000469
-
@@ -8588,53 +6892,6 @@
Difficulty breathing
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -8644,8 +6901,6 @@
Trouble breathing when you exercise
-
-
@@ -8654,8 +6909,6 @@
ARIS:0000472
-
-
@@ -8664,7 +6917,6 @@
ARIS:0000748
-
@@ -8673,7 +6925,6 @@
ARIS:0000473
-
@@ -8682,7 +6933,6 @@
ARIS:0000749
-
@@ -8692,8 +6942,6 @@
Sinus inflammation
-
-
@@ -8702,18 +6950,6 @@
ARIS:0000475
-
-
-
-
-
-
-
-
-
-
-
-
@@ -8722,7 +6958,6 @@
ARIS:0000476
-
@@ -8732,9 +6967,6 @@
Skin stiffening
-
-
-
@@ -8743,7 +6975,6 @@
ARIS:0000478
-
@@ -8752,7 +6983,6 @@
ARIS:0000479
-
@@ -8761,10 +6991,6 @@
ARIS:0000480
-
-
-
-
@@ -8774,14 +7000,6 @@
skin sores
-
-
-
-
-
-
-
-
@@ -8790,7 +7008,6 @@
ARIS:0000482
-
@@ -8799,9 +7016,6 @@
ARIS:0000483
-
-
-
@@ -8810,7 +7024,6 @@
ARIS:0000484
-
@@ -8819,17 +7032,6 @@
ARIS:0000485
-
-
-
-
-
-
-
-
-
-
-
@@ -8838,7 +7040,6 @@
ARIS:0000750
-
@@ -8847,7 +7048,6 @@
ARIS:0000486
-
@@ -8856,7 +7056,6 @@
ARIS:0000487
-
@@ -8865,7 +7064,6 @@
ARIS:0000488
-
@@ -8874,7 +7072,6 @@
ARIS:0000489
-
@@ -8883,7 +7080,6 @@
ARIS:0000490
-
@@ -8892,7 +7088,6 @@
ARIS:0000491
-
@@ -8901,7 +7096,6 @@
ARIS:0000492
-
@@ -8911,10 +7105,6 @@
Throat pain
-
-
-
-
@@ -8923,7 +7113,6 @@
ARIS:0000494
-
@@ -8932,7 +7121,6 @@
ARIS:0000495
-
@@ -8941,7 +7129,6 @@
ARIS:0000496
-
@@ -8950,7 +7137,6 @@
ARIS:0000497
-
@@ -8958,26 +7144,6 @@
Stiffness
ARIS:0000498
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -8986,7 +7152,6 @@
ARIS:0000499
-
@@ -8996,8 +7161,6 @@
Tightness of the skin of the fingers
-
-
@@ -9006,8 +7169,6 @@
ARIS:0000501
-
-
@@ -9016,7 +7177,6 @@
ARIS:0000502
-
@@ -9025,7 +7185,6 @@
ARIS:0000503
-
@@ -9034,7 +7193,6 @@
ARIS:0000751
-
@@ -9043,7 +7201,6 @@
ARIS:0000504
-
@@ -9052,7 +7209,6 @@
ARIS:0000752
-
@@ -9060,41 +7216,6 @@
Swelling
ARIS:0000505
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -9103,7 +7224,6 @@
ARIS:0000506
-
@@ -9112,7 +7232,6 @@
ARIS:0000507
-
@@ -9121,7 +7240,6 @@
ARIS:0000508
-
@@ -9130,10 +7248,6 @@
ARIS:0000509
-
-
-
-
@@ -9142,7 +7256,6 @@
ARIS:0000510
-
@@ -9151,11 +7264,6 @@
ARIS:0000511
-
-
-
-
-
@@ -9164,7 +7272,6 @@
ARIS:0000512
-
@@ -9173,8 +7280,6 @@
ARIS:0000513
-
-
@@ -9183,15 +7288,6 @@
ARIS:0000514
-
-
-
-
-
-
-
-
-
@@ -9200,7 +7296,6 @@
ARIS:0000515
-
@@ -9209,13 +7304,6 @@
ARIS:0000516
-
-
-
-
-
-
-
@@ -9224,7 +7312,6 @@
ARIS:0000517
-
@@ -9233,7 +7320,6 @@
ARIS:0000518
-
@@ -9242,16 +7328,6 @@
ARIS:0000519
-
-
-
-
-
-
-
-
-
-
@@ -9260,8 +7336,6 @@
ARIS:0000520
-
-
@@ -9270,9 +7344,6 @@
ARIS:0000521
-
-
-
@@ -9281,8 +7352,6 @@
ARIS:0000522
-
-
@@ -9291,7 +7360,6 @@
ARIS:0000523
-
@@ -9300,7 +7368,6 @@
ARIS:0000524
-
@@ -9309,7 +7376,6 @@
ARIS:0000525
-
@@ -9318,8 +7384,6 @@
ARIS:0000526
-
-
@@ -9328,7 +7392,6 @@
ARIS:0000527
-
@@ -9337,7 +7400,6 @@
ARIS:0000528
-
@@ -9346,7 +7408,6 @@
ARIS:0000529
-
@@ -9355,7 +7416,6 @@
ARIS:0000753
-
@@ -9364,7 +7424,6 @@
ARIS:0000754
-
@@ -9373,7 +7432,6 @@
ARIS:0000755
-
@@ -9382,14 +7440,6 @@
ARIS:0000530
-
-
-
-
-
-
-
-
@@ -9398,7 +7448,6 @@
ARIS:0000531
-
@@ -9407,7 +7456,6 @@
ARIS:0000532
-
@@ -9416,7 +7464,6 @@
ARIS:0000533
-
@@ -9425,7 +7472,6 @@
ARIS:0000534
-
@@ -9434,7 +7480,6 @@
ARIS:0000535
-
@@ -9443,7 +7488,6 @@
ARIS:0000536
-
@@ -9452,7 +7496,6 @@
ARIS:0000537
-
@@ -9461,7 +7504,6 @@
ARIS:0000538
-
@@ -9470,7 +7512,6 @@
ARIS:0000539
-
@@ -9479,7 +7520,6 @@
ARIS:0000540
-
@@ -9488,7 +7528,6 @@
ARIS:0000541
-
@@ -9497,7 +7536,6 @@
ARIS:0000542
-
@@ -9507,21 +7545,6 @@
Prickling sensations
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -9530,7 +7553,6 @@
ARIS:0000544
-
@@ -9539,8 +7561,6 @@
ARIS:0000545
-
-
@@ -9549,7 +7569,6 @@
ARIS:0000546
-
@@ -9558,7 +7577,6 @@
ARIS:0000547
-
@@ -9567,7 +7585,6 @@
ARIS:0000548
-
@@ -9576,7 +7593,6 @@
ARIS:0000549
-
@@ -9585,9 +7601,6 @@
ARIS:0000550
-
-
-
@@ -9596,7 +7609,6 @@
ARIS:0000551
-
@@ -9605,7 +7617,6 @@
ARIS:0000756
-
@@ -9614,7 +7625,6 @@
ARIS:0000552
-
@@ -9623,7 +7633,6 @@
ARIS:0000757
-
@@ -9632,7 +7641,6 @@
ARIS:0000758
-
@@ -9641,10 +7649,6 @@
ARIS:0000553
-
-
-
-
@@ -9653,7 +7657,6 @@
ARIS:0000759
-
@@ -9662,7 +7665,6 @@
ARIS:0000554
-
@@ -9671,7 +7673,6 @@
ARIS:0000555
-
@@ -9680,17 +7681,6 @@
ARIS:0000556
-
-
-
-
-
-
-
-
-
-
-
@@ -9699,7 +7689,6 @@
ARIS:0000760
-
@@ -9708,7 +7697,6 @@
ARIS:0000557
-
@@ -9717,7 +7705,6 @@
ARIS:0000558
-
@@ -9726,7 +7713,6 @@
ARIS:0000559
-
@@ -9735,7 +7721,6 @@
ARIS:0000560
-
@@ -9744,7 +7729,6 @@
ARIS:0000561
-
@@ -9753,9 +7737,6 @@
ARIS:0000562
-
-
-
@@ -9764,7 +7745,6 @@
ARIS:0000563
-
@@ -9773,17 +7753,6 @@
ARIS:0000564
-
-
-
-
-
-
-
-
-
-
-
@@ -9792,45 +7761,6 @@
ARIS:0000565
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -9839,7 +7769,6 @@
ARIS:0000761
-
@@ -9848,7 +7777,6 @@
ARIS:0000762
-
@@ -9857,7 +7785,6 @@
ARIS:0000566
-
@@ -9867,8 +7794,6 @@
Vitreous floaters and hazy vision
-
-
@@ -9877,7 +7802,6 @@
ARIS:0000567
-
@@ -9886,32 +7810,6 @@
ARIS:0000568
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -9920,7 +7818,6 @@
ARIS:0000569
-
@@ -9929,13 +7826,6 @@
ARIS:0000570
-
-
-
-
-
-
-
@@ -9944,53 +7834,6 @@
ARIS:0000571
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -9999,9 +7842,6 @@
ARIS:0000572
-
-
-
@@ -10010,7 +7850,6 @@
ARIS:0000573
-
@@ -10019,7 +7858,6 @@
ARIS:0000574
-
@@ -10028,9 +7866,6 @@
ARIS:0000575
-
-
-
@@ -10039,7 +7874,6 @@
ARIS:0000576
-
@@ -10048,7 +7882,6 @@
ARIS:0000577
-
@@ -10057,12 +7890,6 @@
ARIS:0000578
-
-
-
-
-
-
@@ -10071,7 +7898,6 @@
ARIS:0000579
-
@@ -10080,7 +7906,6 @@
ARIS:0000580
-
@@ -10089,10 +7914,6 @@
ARIS:0000581
-
-
-
-
@@ -10101,50 +7922,6 @@
ARIS:0000582
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
@@ -10153,7 +7930,6 @@
ARIS:0000764
-
@@ -10162,8 +7938,6 @@
ARIS:0000583
-
-
@@ -10172,7 +7946,6 @@
ARIS:0000584
-
@@ -10181,7 +7954,6 @@
ARIS:0000585
-
@@ -10190,7 +7962,6 @@
ARIS:0000586
-
@@ -10199,7 +7970,6 @@
ARIS:0000587
-
@@ -10208,7 +7978,6 @@
ARIS:0000588
-
@@ -10217,7 +7986,6 @@
ARIS:0000589
-
@@ -10226,7 +7994,6 @@
ARIS:0000590
-
@@ -10235,7 +8002,6 @@
ARIS:0000765
-
@@ -10244,7 +8010,6 @@
ARIS:0000591
-
@@ -10253,8 +8018,6 @@
ARIS:0000592
-
-
@@ -10263,7 +8026,6 @@
ARIS:0000593
-
@@ -10272,12 +8034,6 @@
ARIS:0000594
-
-
-
-
-
-
@@ -10286,13 +8042,6 @@
ARIS:0000595
-
-
-
-
-
-
-
@@ -10301,7 +8050,6 @@
ARIS:0000596
-
diff --git a/notebook/symptom-mapping/build_symptom_mapping.py b/notebook/symptom-mapping/build_symptom_mapping.py
index ba5465f..55d699d 100644
--- a/notebook/symptom-mapping/build_symptom_mapping.py
+++ b/notebook/symptom-mapping/build_symptom_mapping.py
@@ -17,12 +17,14 @@
- Symptoms sheet of report 4: mapping and parent columns after the existing ones
- Symptom Mapping sheet of report 4: one row per symptom string
- ari_symptoms.owl next to this script: a class per mapped symptom under the referenced SYMP terms
+ - symptomConcept on every Symptom individual in ontologies/ari_t1d.owl: the ari_symptoms.owl class
+ its label maps to (the Merged Into row's class for a merged label, none for "not a symptom")
Usage: python build_symptom_mapping.py
The database folder is not tracked in git, so pass the path of a checkout holding symp.owl
(http://purl.obolibrary.org/obo/symp.owl) and hp.obo (http://purl.obolibrary.org/obo/hp.obo).
"""
-import collections, csv, os, sys
+import collections, csv, os, re, sys
import xml.etree.ElementTree as ET
from xml.sax.saxutils import escape, quoteattr
@@ -60,6 +62,10 @@ def obo_iri(curie):
return OBO + curie.replace(":", "_")
+def aris_iri(symptom_id):
+ return f"{BASE}#{symptom_id.replace(':', '_')}"
+
+
def read_symp(path):
"""SYMP CURIE -> (label, [parent CURIEs]) for every non-obsolete term, and the release IRI."""
root = ET.parse(path).getroot()
@@ -243,21 +249,16 @@ def resource(tag, iri):
return f" <{tag} rdf:resource={quoteattr(iri)}/>\n"
-def write_owl(rows, by_name, symp, versions, individuals):
+def write_owl(rows, by_name, symp, versions):
"""A class per exact or broader row, under its parent; SYMP terms it references, with their ancestors."""
def iri(row_id):
- return obo_iri(row_id) if row_id.startswith("SYMP:") else f"{BASE}#{row_id.replace(':', '_')}"
+ return obo_iri(row_id) if row_id.startswith("SYMP:") else aris_iri(row_id)
concepts = [r for r in rows if r["Mapping"] in MAPPED]
alt_labels = collections.defaultdict(list)
for r in rows:
if r["Merged Into"]:
alt_labels[r["Merged Into"]].append(r["Symptom"])
- ind_by_label = collections.defaultdict(list)
- for ind, label in individuals.items():
- r = by_name[label]
- ind_by_label[r["Merged Into"] or label].append(ARI_BASE + ind)
-
needed, stack = set(), [r["SYMP ID"] for r in concepts]
while stack:
curie = stack.pop()
@@ -280,18 +281,15 @@ def iri(row_id):
"and the Human Phenotype Ontology (HPO) for ARI#132, generated from "
"notebook/symptom-mapping/symptom_mapping.tsv. skos:exactMatch names a SYMP or HPO term with the "
"same meaning, skos:broadMatch the nearest broader one. Strings merged into a "
- "symptom are skos:altLabel. ariSymptomIndividual links the Symptom individuals in "
- "ontologies/ari_t1d.owl that carry the symptom. SYMP classes are copied with their labels and "
+ "symptom are skos:altLabel. The Symptom individuals in ontologies/ari_t1d.owl point at their "
+ "class with symptomConcept. SYMP classes are copied with their labels and "
"is_a parents only; HPO terms are referenced by IRI.\n"
+ "".join(f' \n' for v in versions)
+ "\n\n"
'\n'
'\n'
'\n'
- '\n'
- '\n'
- " ARI symptom individual\n"
- "\n\n"
+ '\n\n'
]
for curie in sorted(needed):
out.append(f"\n")
@@ -307,7 +305,6 @@ def iri(row_id):
if curie:
out.append(resource("skos:exactMatch" if mapping == "exact" else "skos:broadMatch", obo_iri(curie)))
out.extend(literal("skos:altLabel", a) for a in sorted(alt_labels[r["Symptom"]]))
- out.extend(resource("ariSymptomIndividual", i) for i in sorted(ind_by_label[r["Symptom"]]))
out.extend(resource("rdfs:subClassOf", iri(p[1])) for p in parents_of(r, by_name, symp))
out.append("\n\n")
out.append("\n")
@@ -316,6 +313,38 @@ def iri(row_id):
return len(concepts), len(needed)
+def write_ontology_links(by_name, individuals):
+ """Set symptomConcept on every Symptom individual in ari_t1d.owl from its label's row.
+
+ Edits the file line by line so nothing else in it moves: a symptomConcept line inside a Symptom
+ individual is dropped, and the one its label maps to is written after its rdfs:label.
+ """
+ text = open(ONTOLOGY, encoding="utf-8", newline="").read()
+ if '' not in text:
+ raise SystemExit(f"{ONTOLOGY} does not declare the symptomConcept annotation property")
+ opening = re.compile(r'<[\w:]+ rdf:about="(#[^"]+)">')
+ out, current, linked = [], None, 0
+ for line in text.splitlines(keepends=True):
+ match = opening.match(line)
+ if match and match.group(1) in individuals:
+ current = match.group(1)
+ elif current and line.startswith(""):
+ current = None
+ if current and line.lstrip().startswith("{ending}')
+ linked += 1
+ with open(ONTOLOGY, "w", encoding="utf-8", newline="") as f:
+ f.write("".join(out))
+ return linked
+
+
def main():
if len(sys.argv) != 2:
raise SystemExit(__doc__)
@@ -332,13 +361,15 @@ def main():
raise SystemExit(f"{len(missing)} symptoms have no row in symptom_mapping.tsv: {missing}")
write_report(by_name, symp, ontology_diseases)
- classes, symp_classes = write_owl(rows, by_name, symp, [symp_version, hp_version], individuals)
+ classes, symp_classes = write_owl(rows, by_name, symp, [symp_version, hp_version])
+ linked = write_ontology_links(by_name, individuals)
counts = collections.Counter(r["Mapping"] for r in rows)
print(f"{len(rows)} symptom strings: " + ", ".join(f"{n} {k}" for k, n in sorted(counts.items())))
hpo = collections.Counter(r["HPO Mapping"] for r in rows if r["HPO Mapping"])
print("HPO: " + ", ".join(f"{n} {k}" for k, n in sorted(hpo.items())))
print(f"{sum(1 for r in rows if r['Parent Symptom'])} grouped under an ARI parent symptom")
print(f"{classes} ARI symptom classes, {symp_classes} SYMP classes -> {OUT}")
+ print(f"{linked} of {len(individuals)} Symptom individuals linked by symptomConcept -> {ONTOLOGY}")
if __name__ == "__main__":
diff --git a/ontologies/ari_t1d.owl b/ontologies/ari_t1d.owl
index a6c9499..8c5ee2a 100644
--- a/ontologies/ari_t1d.owl
+++ b/ontologies/ari_t1d.owl
@@ -254,6 +254,11 @@
+
+ symptom concept
+ The shared ARI symptom (an ARIS class in notebook/symptom-mapping/ari_symptoms.owl) that this per-disease Symptom individual is. Written by notebook/symptom-mapping/build_symptom_mapping.py from the curated symptom_mapping.tsv, keyed by the individual's label.
+
+
UBERON:0010000
@@ -749,6 +754,7 @@
Polyuria
+
Very common (>=90%)
Excessive urination due to osmotic diuresis from hyperglycemia
HP:0100626
@@ -759,6 +765,7 @@
Polydipsia
+
Very common (>=90%)
Excessive thirst caused by dehydration from osmotic diuresis
HP:0100627
@@ -769,6 +776,7 @@
Unintended weight loss
+
Common (60-80%)
Weight loss despite normal/increased appetite
HP:0001824
@@ -779,6 +787,7 @@
Fatigue
+
Common (60-80%)
Chronic tiredness from metabolic dysregulation
HP:0012378
@@ -789,6 +798,7 @@
Blurred vision
+
Moderate (20-40%)
Lens swelling due to hyperglycemia
HP:0025147
@@ -799,6 +809,7 @@
Diabetic ketoacidosis (DKA)
+
Variable (25-40%)
Metabolic decompensation with ketone production
HP:0001953
@@ -809,6 +820,7 @@
Recurrent infections
+
Moderate
Increased susceptibility to skin, UT, and yeast infections
HP:0002718
@@ -819,6 +831,7 @@
Nocturia
+
Moderate (30-50%)
Nighttime urination from impaired renal concentrating ability
HP:0000017
@@ -829,6 +842,7 @@
Irritability / mood changes
+
Common (40-60%)
Behavioral changes from hyperglycemia
HP:0000737
@@ -839,6 +853,7 @@
Increased appetite (polyphagia)
+
Common (50-70%)
Excessive hunger despite high blood glucose
HP:0002591
@@ -1698,6 +1713,7 @@
Polydipsia
+
HP:0100627
https://pubmed.ncbi.nlm.nih.gov/26494507/
Common (50-70%)
@@ -1708,6 +1724,7 @@
Gradual weight loss
+
HP:0001824
https://pubmed.ncbi.nlm.nih.gov/26494507/
Moderate
@@ -1775,6 +1792,7 @@
Fulminant ketoacidosis
+
Very common (>=90%)
Severe DKA within days of symptom onset
HP:0001953
@@ -1785,6 +1803,7 @@
Flu-like prodrome
+
Common (70%)
Preceding viral-like illness before abrupt onset
HP:0033273
@@ -1884,18 +1903,21 @@
Blisters
+
false
Blisters on various mucous membranes
+
false
Widespread blisters that are not localized to trauma-prone sites
+
false
@@ -1914,18 +1936,21 @@
Mucous-membrane blisters that rupture easily
+
false
Scarring
+
false
When blisters heal they form scars and sometimes tiny white bumps
+
false
@@ -1944,12 +1969,14 @@
Tense, blood- or pus-filled blisters, mostly on the hands, knees, knuckles, elbows and ankles
+
false
Widespread redness and itching
+
false
@@ -2053,48 +2080,56 @@
Swelling
+
false
Blood in stool
+
false
Blood in urine
+
false
Easy bruising
+
false
Urogenital bleeding
+
false
Excessive bleeding
+
false
Nosebleeds
+
false
Solid swellings of congealed blood
+
false
@@ -2198,78 +2233,91 @@
Vision problems
+
false
Weakness in legs
+
false
Weakness in arms
+
false
Confusion
+
false
Drowsiness
+
false
Unsteadiness
+
false
Falling
+
false
Blurred vision
+
false
Double vision, horizontal or vertical, that improves when one eye is closed
+
false
Difficulty swallowing
+
false
Seizures
+
false
Weakness
+
false
Double vision
+
false
@@ -2377,114 +2425,133 @@ The cause of Kawasaki's Disease is uncertain but is believed to be autoimmune.
Swelling
+
false
Pain
+
false
Irregular heartbeat
+
false
Peeling skin
+
false
Joint pain
+
false
Hearing loss
+
false
Vomiting
+
false
Diarrhea
+
false
Abdominal pain
+
false
Fever
+
false
Red eyes
+
false
Swollen feet
+
false
Swollen hands
+
false
Skin discoloration
+
false
Red, dry, cracked, and swollen lips
+
false
Rash on groin
+
false
Rash on torso
+
false
Swollen tongue that looks shiny and bright with red spots
+
false
Rash
+
false
@@ -2566,24 +2633,28 @@ The cause of Kawasaki's Disease is uncertain but is believed to be autoimmune.
Bumps on skin containing pus
+
false
Bumps on skin containing blood
+
false
Red patches that quickly turn into small bumps 5-15 mm in diameter
+
false
Red patches may be covered with a fine shiny scale
+
false
@@ -2698,108 +2769,126 @@ The cause of Kawasaki's Disease is uncertain but is believed to be autoimmune.
Pain
+
false
Joint pain
+
false
Abdominal pain
+
false
Muscle pain
+
false
Weakness
+
false
Fatigue
+
false
Weight loss
+
false
Hyperpigmentation
+
false
Salt craving
+
false
Nausea
+
false
Diarrhea
+
false
Vomiting
+
false
Irritability
+
false
Depression
+
false
Body hair loss
+
false
Sexual dysfunction
+
false
Mouth sores
+
false
Fainting
+
false
@@ -2962,96 +3051,112 @@ The cause of Kawasaki's Disease is uncertain but is believed to be autoimmune.
Swelling
+
false
Pain
+
false
Joint pain
+
false
Joint stiffness
+
false
A salmon/pink-colored rash on chest and thighs during fever
+
false
Sore throat
+
false
Difficulty breathing
+
false
Stiffness
+
false
Muscle pain
+
false
Weight loss
+
false
Swelling in armpits
+
false
Swelling in neck
+
false
Fever
+
false
Abdominal pain
+
false
Swollen joints
+
false
Rash
+
false
@@ -3125,24 +3230,28 @@ However, based on the research available at this time, there is no evidence that
Vision problems
+
false
Blurred vision
+
false
Dark spots in vision
+
false
Hard to read fine print, drive, or recognize faces
+
false
@@ -3232,36 +3341,42 @@ However, based on the research available at this time, there is no evidence that
Beard hair loss
+
false
Eyebrow hair loss
+
false
Loss of eyelashes
+
false
Scalp hair loss
+
false
Hair loss
+
false
Fingernails and toenails have dents, white spots, and roughness
+
false
@@ -3359,90 +3474,105 @@ However, based on the research available at this time, there is no evidence that
Swelling
+
false
Weakness
+
false
Weakness in hands
+
false
Loss of feeling in hands
+
false
Weight loss
+
false
Abnormal lumps below skin
+
false
A feeling of fullness or pressure in the chest or abdomen that can cause difficulty breathing or eating
+
false
Cough
+
false
Vomiting
+
false
Fever
+
false
Night sweats
+
false
Nausea
+
false
Fatigue
+
false
Swollen feet
+
false
Swollen ankles
+
false
@@ -3542,102 +3672,119 @@ However, based on the research available at this time, there is no evidence that
Pain
+
false
Pain in tendons
+
false
Heel stiffness
+
false
Weight loss
+
false
Heel pain
+
false
Lower back stiffness
+
false
Pain in ligaments
+
false
Eye inflammation
+
false
Hip stiffness
+
false
Hip pain
+
false
Fever
+
false
Fatigue
+
false
Difficulty breathing
+
false
Pain in buttocks
+
false
Back pain
+
false
Stiffness of the buttocks
+
false
Stiffness
+
false
@@ -3739,54 +3886,63 @@ However, based on the research available at this time, there is no evidence that
Pain
+
false
Burning
+
false
Fatigue
+
false
Difficulty breathing
+
false
Vomiting
+
false
Nausea
+
false
Burning feeling when urinating
+
false
Chest pain
+
false
Weakness
+
false
@@ -4005,54 +4161,63 @@ However, based on the research available at this time, there is no evidence that
Weakness
+
false
Fever
+
false
Weight loss
+
false
Night sweats
+
false
Headache
+
false
Numbness
+
false
Pain
+
false
Fatigue
+
false
Rash
+
false
@@ -4149,24 +4314,28 @@ There's no cure for antiphospholipid syndrome, but medications can reduce the ri
Rash
+
false
Deep vein thrombosis
+
false
Miscarriages
+
false
Stillbirths
+
false
@@ -4263,60 +4432,70 @@ The trigger for antisynthetase syndrome is unknown, but it may be associated wit
Pain
+
false
Joint pain
+
false
Bluish coloring of hands/feet
+
false
Cough
+
false
Foot pain
+
false
Muscle pain
+
false
Shortness of breath
+
false
Fever
+
false
Thickened skin of fingers
+
false
Weight loss
+
false
@@ -4490,78 +4669,91 @@ The trigger for antisynthetase syndrome is unknown, but it may be associated wit
Irregular heartbeat
+
false
Rash
+
false
Rapid heartbeat
+
false
Frequent infections
+
false
Easy bruising
+
false
Fatigue
+
false
Shortness of breath with exertion
+
false
Pale skin
+
false
Nosebleeds
+
false
Bleeding gums
+
false
Prolonged bleeding from cuts
+
false
Dizziness
+
false
Headache
+
false
@@ -4691,48 +4883,56 @@ The trigger for antisynthetase syndrome is unknown, but it may be associated wit
Swelling
+
false
Swollen lips
+
false
Swollen hands
+
false
Swollen feet
+
false
Nausea
+
false
Vomiting
+
false
Pain
+
false
Difficulty breathing
+
false
@@ -4919,24 +5119,28 @@ The trigger for antisynthetase syndrome is unknown, but it may be associated wit
Hearing loss that may fluctuate, particularly early in the course of the disease
+
false
Ringing in the ear
+
false
Feeling of fullness in the ear
+
false
Vertigo
+
false
@@ -5046,66 +5250,77 @@ The trigger for antisynthetase syndrome is unknown, but it may be associated wit
Seizures
+
false
Vision problems
+
false
Euphoria
+
false
Fear
+
false
Panic attacks
+
false
Compulsive behavior
+
false
Unsteady gait
+
false
Cognitive impairment
+
false
Abnormal movement
+
false
Memory problems
+
false
Psychosis
+
false
@@ -5215,84 +5430,98 @@ When the NMDA receptor antibodies attack the NMDA receptors in the brain, certai
Fever
+
false
Nausea
+
false
Fatigue
+
false
Anxiety
+
false
Confusion
+
false
Hallucinations
+
false
Aggression
+
false
Paranoid delusions
+
false
Difficulty speaking
+
false
Memory problems
+
false
Mood changes
+
false
Seizures
+
false
Stiffness
+
false
Sleep problems
+
false
@@ -5459,78 +5688,91 @@ When the NMDA receptor antibodies attack the NMDA receptors in the brain, certai
Pain
+
false
Burning
+
false
Abdominal bloating
+
false
Indigestion
+
false
Acid reflux/heartburn
+
false
Hiccups
+
false
Nausea
+
false
Vomiting
+
false
Weakness
+
false
Fatigue
+
false
Feeling full quickly after eating
+
false
Gnawing ache in the upper abdomen that may become better or worse with eating
+
false
Burning pain in the upper abdomen that may become better or worse with eating
+
false
@@ -5615,60 +5857,70 @@ When the NMDA receptor antibodies attack the NMDA receptors in the brain, certai
Pain
+
false
Weakness
+
false
Muscle pain
+
false
Fatigue
+
false
Difficulty breathing
+
false
Shortness of breath
+
false
Headache
+
false
Dizziness
+
false
Rapid heartbeat
+
false
Chills
+
false
@@ -5776,78 +6028,91 @@ When the NMDA receptor antibodies attack the NMDA receptors in the brain, certai
Pain
+
false
Diarrhea
+
false
Joint pain
+
false
Rash
+
false
Fatigue
+
false
Muscle pain
+
false
Edema
+
false
Abnormal skin blood vessels
+
false
Dark urine
+
false
Nausea
+
false
Vomiting
+
false
Abdominal pain
+
false
Yellow eyes
+
false
@@ -6165,24 +6430,28 @@ When the NMDA receptor antibodies attack the NMDA receptors in the brain, certai
Low blood counts
+
false
Fatigue
+
false
Yellow skin
+
false
Frequent infections
+
false
@@ -6327,48 +6596,56 @@ In chronic autoimmune neutropenia the body produces IgG antibodies that target a
Frequent infections
+
false
Mouth ulcers
+
false
Inflammation of the gums
+
false
Sore throat
+
false
Chest infections
+
false
Diarrhea
+
false
Chills
+
false
Fatigue
+
false
@@ -6457,102 +6734,119 @@ In chronic autoimmune neutropenia the body produces IgG antibodies that target a
Pain
+
false
Abdominal cramps
+
false
Burning feeling when urinating
+
false
Absent menstrual period
+
false
Pain during urination
+
false
Pelvic pain
+
false
Infertility
+
false
Bleeding between menstrual cycles
+
false
Pain during sexual intercourse
+
false
Heavy vaginal discharge that has a foul odor
+
false
Difficulty urinating
+
false
Abdominal bloating
+
false
Nausea
+
false
Vomiting
+
false
Fever
+
false
Chills
+
false
Burning
+
false
@@ -6715,72 +7009,84 @@ In chronic autoimmune neutropenia the body produces IgG antibodies that target a
Pain
+
false
Weight loss
+
false
Vomiting
+
false
Yellow eyes
+
false
Loose fatty stools that do not flush easily
+
false
Nausea
+
false
Abdominal pain
+
false
Yellow skin
+
false
Fatigue
+
false
Back pain
+
false
Diarrhea
+
false
Shortness of breath
+
false
@@ -6793,6 +7099,7 @@ In chronic autoimmune neutropenia the body produces IgG antibodies that target a
Increased thirst
+
false
@@ -6860,48 +7167,56 @@ In chronic autoimmune neutropenia the body produces IgG antibodies that target a
Swelling
+
false
Hives
+
false
Spots
+
false
Swelling beneath the skin
+
false
Eczema-like rash
+
false
Circular rash
+
false
Mouth sores
+
false
Rash
+
false
@@ -7103,24 +7418,28 @@ In chronic autoimmune neutropenia the body produces IgG antibodies that target a
Apparent flashes of light
+
false
Vision loss
+
false
Vision problems
+
false
Loss of low-light vision
+
false
@@ -7272,150 +7591,175 @@ Several names are used for autoimmune thyroiditis. When it is known to be autoim
Pain
+
false
Stiffness
+
false
Joint pain
+
false
Heavy menstrual flow
+
false
Muscle pain
+
false
Sensitivity to extreme cold
+
false
Tenderness
+
false
Hip stiffness
+
false
Brittle fingernails
+
false
Memory problems
+
false
Loss of feeling in feet
+
false
Loss of feeling in hands
+
false
Hoarseness
+
false
Fatigue
+
false
Constipation
+
false
Pale skin
+
false
Dry skin
+
false
Hair loss
+
false
Weight gain
+
false
Depression
+
false
Sluggishness
+
false
Decreased sweating
+
false
Galactorrhea
+
false
Muscle cramps
+
false
Daytime sleepiness
+
false
@@ -7509,18 +7853,21 @@ Urticaria can also be caused by allergic reaction to plants like poison ivy, dye
Swelling
+
false
Red or skin colored welts, can vary in size, shape and appear anywhere on the body
+
false
Severe itching
+
false
@@ -7533,12 +7880,14 @@ Urticaria can also be caused by allergic reaction to plants like poison ivy, dye
Swollen lips
+
false
Difficulty breathing
+
false
@@ -7711,108 +8060,126 @@ There are many types of vasculitis, and most of them are rare. Vasculitis might
Pain
+
false
Dizziness
+
false
Ringing in ears
+
false
Hearing loss
+
false
Redness
+
false
Numbness
+
false
Dark urine
+
false
Rash
+
false
Cough
+
false
Difficulty breathing
+
false
Tingling
+
false
Fever
+
false
Fatigue
+
false
Malaise
+
false
Weight loss
+
false
Joint pain
+
false
Abdominal pain
+
false
Blood in urine
+
false
@@ -7897,42 +8264,49 @@ There are many types of vasculitis, and most of them are rare. Vasculitis might
Muscle spasms
+
false
Paralysis
+
false
Seizures
+
false
Cognitive impairment
+
false
Difficulty understanding speech
+
false
Fever
+
false
Difficulty speaking
+
false
@@ -8049,138 +8423,161 @@ This disease is not well understood but is believed to be autoimmune in nature s
Swelling
+
false
Pain
+
false
Headache
+
false
Weakness in facial muscles
+
false
Throat muscle weakness
+
false
Blurred vision
+
false
Unsteady gait
+
false
Swollen legs
+
false
Leg pain
+
false
Mouth ulcers
+
false
Eye pain
+
false
Arm pain
+
false
Raised and tender/painful nodules on the skin, especially on the lower legs
+
false
Painful genital sores
+
false
Joint pain
+
false
Skin pain
+
false
Abdominal pain
+
false
Diarrhea
+
false
Fever
+
false
Disorientation
+
false
Eye inflammation
+
false
Vision problems
+
false
Weakness
+
false
@@ -8276,66 +8673,77 @@ Cicatricial pemphigoid is usually not chronic, and most patients symptoms disapp
Pain
+
false
Seizures
+
false
Eye sensitivity
+
false
Blisters
+
false
Eye inflammation
+
false
Blindness
+
false
Weight loss
+
false
Pain when urinating
+
false
Itching
+
false
Painful and sensitive blisters that are ruptured
+
false
Lesions
+
false
@@ -8554,48 +8962,56 @@ Cicatricial pemphigoid is usually not chronic, and most patients symptoms disapp
Blisters
+
false
Difficulty swallowing
+
false
Large blisters on lower abdomen, groin, upper thighs and arms that don't easily rupture when touched
+
false
Blisters in infants
+
false
Blister inside mouth
+
false
Hives
+
false
Blisters on eyes
+
false
Wart-like plaques on areas of the skin, such as the armpit, neck, groin, and breasts
+
false
@@ -8608,6 +9024,7 @@ Cicatricial pemphigoid is usually not chronic, and most patients symptoms disapp
In childhood-onset bullous pemphigoid associated with vaccination, the bullous lesions predominantly affect the palms, soles, and face
+
false
@@ -8873,30 +9290,35 @@ The first reports of narcolepsy being an autoimmune disease came in 2013, but re
Daytime sleepiness
+
false
Weakness
+
false
Sleep problems
+
false
Paralysis while falling asleep or upon waking up
+
false
Vivid, dream-like experiences when falling asleep or upon waking up
+
false
@@ -9076,192 +9498,224 @@ CD is generally treated by eliminating gluten from the diet. Patients with an e
Swelling
+
false
Pain
+
false
Delayed puberty
+
false
Damage to dental enamel
+
false
Behavioral changes
+
false
Joint pain
+
false
Abdominal pain
+
false
Headache
+
false
Swollen hands
+
false
Bone pain
+
false
Swollen feet
+
false
Miscarriages
+
false
Infertility
+
false
Heavy menstrual flow
+
false
Fatigue
+
false
Weakness
+
false
Bloating
+
false
Gas
+
false
Acid reflux/heartburn
+
false
Nausea
+
false
Vomiting
+
false
Diarrhea
+
false
Constipation
+
false
Lactose intolerance
+
false
Weight loss
+
false
Easy bruising
+
false
Depression
+
false
Canker sores
+
false
Irritability
+
false
Learning disability
+
false
Short stature
+
false
Failure to thrive
+
false
@@ -9389,24 +9843,28 @@ The cause of this syndrome is unknown, however, researchers believe that it may
Dizziness
+
false
Pain
+
false
Fatigue
+
false
Sleep problems
+
false
@@ -9419,6 +9877,7 @@ The cause of this syndrome is unknown, however, researchers believe that it may
Malaise
+
false
@@ -9547,54 +10006,63 @@ The cause of this syndrome is unknown, however, researchers believe that it may
Double vision
+
false
Weakness in hip
+
false
Unsteady gait
+
false
Reduced reflexes
+
false
Weakness in hands
+
false
Pain
+
false
Weakness in feet
+
false
Vision problems
+
false
Weakness
+
false
@@ -9721,54 +10189,63 @@ Currently, the cause of interstitial cystitis is unknown. There are two main the
Pain
+
false
Increased frequency of urination
+
false
Bladder pain
+
false
Pain or discomfort while the bladder fills and relief after urinating
+
false
Abdominal pain
+
false
Pain during sexual intercourse
+
false
Vaginal pain
+
false
Penis pain
+
false
Testicle pain
+
false
@@ -9902,138 +10379,161 @@ However, in some people, the Lyme disease triggers symptoms similar to rheumatoi
Pain
+
false
Rash
+
false
Fever
+
false
Chills
+
false
Fatigue
+
false
Muscle pain
+
false
Headache
+
false
Joint pain
+
false
Facial paralysis
+
false
Weakness in facial muscles
+
false
Sleep problems
+
false
Malaise
+
false
Heart palpitations
+
false
Decreased movement
+
false
Concentration loss
+
false
Numbness
+
false
Muscle stiffness
+
false
Joint stiffness
+
false
Nausea
+
false
Vomiting
+
false
Brain fog
+
false
Stiffness
+
false
Weakness
+
false
@@ -10158,144 +10658,168 @@ Chronic non-bacterial osteomyelitis (CNO) is a rare auto-inflammatory bone disor
Pain
+
false
Tingling
+
false
Hand pain
+
false
Irritability
+
false
Ringing in ears
+
false
Back pain
+
false
Leg pain
+
false
Joint pain
+
false
Fatigue
+
false
Bluish coloring of hands/feet
+
false
Foot pain
+
false
Dizziness
+
false
Headache
+
false
Cold hands
+
false
Cold feet
+
false
Chest pain
+
false
Irregular heartbeat
+
false
Nausea
+
false
Vomiting
+
false
Diarrhea
+
false
Weakness
+
false
Weight loss
+
false
Behavioral changes
+
false
Pain or discomfort in swallowing cold foods and liquids
+
false
@@ -10444,48 +10968,56 @@ More study is needed.
Vomiting
+
true
Weight loss
+
true
Loose fatty stools that do not flush easily
+
true
Nausea
+
true
Fatigue
+
false
Diarrhea
+
true
Shortness of breath
+
false
Increased thirst
+
true
@@ -10601,102 +11133,119 @@ More study is needed.
Cramps
+
false
Hearing loss
+
false
Ringing in ears
+
false
Unsteady gait
+
false
Pain
+
false
Sensitivity to light
+
false
Red eyes
+
false
Blurred vision
+
false
Dizziness
+
false
Nausea
+
false
Vomiting
+
false
Fever
+
false
Fatigue
+
false
Eye pain
+
false
Vertigo
+
false
Weight loss
+
false
Vision problems
+
false
@@ -10845,102 +11394,119 @@ More study is needed.
Pain
+
false
Heart murmur
+
false
Irregular heartbeat
+
false
Fatigue
+
false
Dizziness
+
false
Headache
+
false
Coldness
+
false
Pale skin
+
false
Dark urine
+
false
Yellow skin
+
false
Chest pain
+
false
Back pain
+
false
Leg pain
+
false
Vomiting
+
false
Diarrhea
+
false
Bluish coloring of hands/feet
+
false
Skin discoloration
+
false
@@ -11157,84 +11723,98 @@ More study is needed.
Pain
+
false
Burning
+
false
Throbbing pain in limbs
+
false
Changes in nails
+
false
Skin discoloration
+
false
Muscle spasms
+
false
Burning sensation
+
false
Changes in hair
+
false
Skin temperature changes
+
false
Skin texture changes
+
false
Sensitivity to touch
+
false
Sensitivity to extreme cold
+
false
Weakness
+
false
Tremor
+
false
@@ -11460,78 +12040,91 @@ Both UC and CD are caused by an autoimmune response that reflects the involvemen
Pain
+
false
Abdominal pain
+
false
Delayed puberty
+
false
Delayed growth
+
false
Abdominal cramps
+
false
Diarrhea
+
false
Fever
+
false
Fatigue
+
false
Blood in stool
+
false
Mouth sores
+
false
Weight loss
+
false
Eye inflammation
+
false
Skin disorders
+
false
@@ -11647,30 +12240,35 @@ Both UC and CD are caused by an autoimmune response that reflects the involvemen
Weight loss
+
false
Difficulty breathing
+
false
Fever
+
false
Fatigue
+
false
Cough
+
false
@@ -11841,30 +12439,35 @@ Both UC and CD are caused by an autoimmune response that reflects the involvemen
Pain
+
false
Painful rashes
+
false
Painful sores
+
false
Thinning of skin
+
false
Brittle fingernails
+
false
@@ -11877,18 +12480,21 @@ Both UC and CD are caused by an autoimmune response that reflects the involvemen
Hair loss
+
false
Skin discoloration
+
false
Rash
+
false
@@ -11962,36 +12568,42 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Pain
+
false
Rapid heartbeat
+
false
Abnormal growths/lesions on the skin that may be painful
+
false
Diarrhea
+
false
Fast breathing
+
false
Difficulty breathing
+
false
@@ -12085,72 +12697,84 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Burning
+
false
Pain
+
false
Rash
+
false
Itchy rash
+
false
Burning rash
+
false
Stinging rash
+
false
Sensitivity to gluten
+
false
Abdominal bloating
+
false
Cramps
+
false
Abdominal pain
+
false
Diarrhea
+
false
Constipation
+
false
@@ -12249,48 +12873,56 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Rash
+
false
Weakness
+
false
Progressive, symmetrical muscle weakness
+
false
Violet/dusky red rash
+
false
Scalp discoloration
+
false
Difficulty swallowing
+
false
Tenderness
+
false
Fatigue
+
false
@@ -12385,72 +13017,84 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Erectile dysfunction
+
false
Weakness
+
false
Bowel changes
+
false
Dry mouth
+
false
Bladder changes
+
false
Eyelid drooping
+
false
Weakness in arms
+
false
Weakness in legs
+
false
Fatigue
+
false
Dry eyes
+
false
Difficulty swallowing
+
false
Difficulty chewing
+
false
@@ -12645,90 +13289,105 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Pain
+
false
Pain after sexual intercourse
+
false
Painful menstrual periods
+
false
Heavy menstrual flow
+
false
Bleeding between menstrual cycles
+
false
Painful cramps during menstrual periods
+
false
Pain and/or cramps in the lower abdomen before menstruation
+
false
Pain when urinating during menstrual periods
+
false
Painful bowel movements during menstrual periods
+
false
Infertility
+
false
Fatigue
+
false
Diarrhea
+
false
Constipation
+
false
Bloating during menstrual periods
+
false
Nausea during menstrual periods
+
false
@@ -12817,96 +13476,112 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Swelling
+
false
Pain
+
false
Toe pain
+
false
Heel pain
+
false
Hip pain
+
false
Knee pain
+
false
Back pain
+
false
Elbow pain
+
false
Pain on the bottom of the foot, especially noticeable when moving
+
false
Swollen heel
+
false
Swollen knees
+
false
Swollen hip
+
false
Swollen toes
+
false
Swollen elbows
+
false
Swollen back
+
false
Swollen feet
+
false
@@ -12990,48 +13665,56 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Chest pain
+
false
Indigestion
+
false
Acid reflux/heartburn
+
false
Abdominal pain
+
false
Poor weight gain
+
false
Difficulty swallowing
+
false
Vomiting
+
false
Food getting stuck in the esophagus after swallowing
+
false
@@ -13044,18 +13727,21 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Pain
+
false
Difficulty eating
+
false
Failure to thrive
+
false
@@ -13149,6 +13835,7 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Confusion
+
false
@@ -13161,60 +13848,70 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Loss of consciousness
+
false
Seizures
+
false
Involuntary movements
+
false
Fear
+
false
Anxiety
+
false
Changes in senses
+
false
Dizziness
+
false
Tingling
+
false
Seeing flashing lights
+
false
Repetitive movements
+
false
@@ -13292,30 +13989,35 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Burning
+
false
Sensitivity to light
+
false
Burning/gritty sensation in eyes
+
false
Eye irritation
+
false
Watery eyes
+
false
@@ -13399,66 +14101,77 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Swelling
+
false
Pain
+
false
Fever
+
false
Joint pain
+
false
Abdominal pain
+
false
Flu-like symptoms
+
false
Abnormal lumps below skin
+
false
Painful, symmetrical lumps
+
false
Pain when standing
+
false
Swollen ankles
+
false
Lumps turn blue or yellow
+
false
@@ -13545,42 +14258,49 @@ When mastocytosis is not limited to the skin, it is called systemic mastocytosis
Tingling
+
false
Skin discoloration
+
false
Lesions
+
false
Easy bruising
+
false
Hives
+
false
Numbness in the fingers or toes, especially in cold temperatures
+
false
Tingling in the fingers or toes, especially in cold temperatures
+
false
@@ -13670,54 +14390,63 @@ The disorder resembles a combination of autoimmune hemolytic anemia, thrombocyto
Mouth sores
+
false
Weakness
+
false
Fatigue
+
false
Shortness of breath
+
false
Easy bruising
+
false
Nosebleeds
+
false
Skin discoloration
+
false
Frequent infections
+
false
Fever
+
false
@@ -13820,114 +14549,133 @@ The disorder resembles a combination of autoimmune hemolytic anemia, thrombocyto
Burning
+
false
Tingling
+
false
Burning sensation in hand
+
false
Pain
+
false
Wrist pain
+
false
Hand pain
+
false
Tingling of wrist
+
false
Burning sensation in wrist
+
false
Skin hardening
+
false
Tingling of hand
+
false
Pain in extremities
+
false
Skin stiffening
+
false
Muscle pain
+
false
Joint pain
+
false
Tenderness
+
false
Redness
+
false
Swelling
+
false
Orange peel appearance of skin of the extremities
+
false
Skin texture changes
+
false
@@ -14026,54 +14774,63 @@ The disorder resembles a combination of autoimmune hemolytic anemia, thrombocyto
Swelling
+
false
Stiffness
+
false
Pain
+
false
Joint pain
+
false
Joint stiffness
+
false
Swollen joints
+
false
Fever
+
false
Fatigue
+
false
Weight loss
+
false
@@ -14230,48 +14987,56 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Fatigue
+
false
Sleep problems
+
false
Tenderness
+
false
Pain
+
false
Cognitive impairment
+
false
Stiffness
+
false
Muscle tenderness
+
false
Tendon tenderness
+
false
@@ -14390,126 +15155,147 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Finger tremor
+
false
Sensitivity to extreme heat
+
false
Thickened red skin
+
false
Heavy menstrual flow
+
false
Easy bruising
+
false
Hand tremor
+
false
Anxiety
+
false
Irritability
+
false
An increase in perspiration or warm, moist skin
+
false
Rapid heartbeat
+
false
Irregular heartbeat
+
false
Weight loss
+
false
Erectile dysfunction
+
false
Reduced libido
+
false
Frequent bowel movements
+
false
Fatigue
+
false
Sleep problems
+
false
Bulging eyes
+
false
Swelling
+
false
Swelling in neck
+
false
Tremor
+
false
@@ -14621,150 +15407,175 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Tingling
+
false
Loss of bowel control
+
false
Difficulty speaking
+
false
Difficulty swallowing
+
false
Loss of bladder control
+
false
Paralysis of eye muscles
+
false
Lightheadedness
+
false
Unsteady gait
+
false
Weakness in legs
+
false
Tingling of extremities
+
false
Pain
+
false
Weakness in upper body
+
false
Facial droop
+
false
Double vision, horizontal or vertical, that improves when one eye is closed
+
false
Dysfunction of pupils
+
false
Facial flushing
+
false
Lack of sweat
+
false
Excessive sweating
+
false
Difficulty breathing
+
false
Vision problems
+
false
Weakness
+
false
Difficulty climbing stairs
+
false
Cramps
+
false
Irregular heartbeat
+
false
Double vision
+
false
@@ -14870,30 +15681,35 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Blisters
+
false
Patches of blisters
+
false
Large blisters
+
false
Red bumps on abdomen
+
false
Hives
+
false
@@ -14973,36 +15789,42 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Painful red bumps that enlarge, break open, and drain pus. the pus may have an unpleasant odor
+
false
Leaking bumps or sores that heal very slowly and recur over time
+
false
Pain
+
false
Abnormal lumps below skin
+
false
Scarring
+
false
Small pitted areas of skin containing blackheads
+
false
@@ -15082,36 +15904,42 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Rash with tender, purple or brownish-red spots
+
false
Skin sores
+
false
Skin blisters
+
false
Hives
+
false
Blisters
+
false
Rash
+
false
@@ -15269,36 +16097,42 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Weight loss
+
false
Dry cough
+
false
Shortness of breath
+
false
Fatigue
+
false
Swollen fingers
+
false
Swelling
+
false
@@ -15391,60 +16225,70 @@ ASA is not a concern except for people trying to conceive. Findings include a se
Muscle pain
+
false
Dark urine
+
false
Joint pain
+
false
Swollen hands
+
false
Swollen feet
+
false
Foamy, frothy urine
+
false
Back pain
+
false
Blood in urine
+
false
Swelling
+
false
Pain
+
false
@@ -15725,90 +16569,105 @@ Note that thrombotic thrombocytopenic purpura, TTP, is a ***genetic*** disease t
Blisters
+
false
Nosebleeds
+
false
Yellow skin
+
false
Easy bruising
+
false
Tiny reddish-purple spots, usually on lower legs
+
false
Prolonged bleeding from cuts
+
false
Rupturing blisters
+
false
Blood in urine
+
false
Purple skin where blood has collected just beneath the surface of the skin
+
false
Headache
+
false
Blood in stool
+
false
Bleeding gums
+
false
Fatigue
+
false
Heavy menstrual flow
+
false
Drowsiness
+
false
@@ -15909,72 +16768,84 @@ This condition is usually temporary (4-6 weeks) with a full recovery for most pa
Purplish rash, typically on the lower legs and buttocks
+
false
Abdominal pain
+
false
Joint pain
+
false
Blood in urine
+
false
Headache
+
false
Blood in stool
+
false
Swollen penis
+
false
Swollen testicles
+
false
Difficulty breathing
+
false
Swelling
+
false
Rash
+
false
Pain
+
false
@@ -16258,54 +17129,63 @@ At this time, not all IgG4 diseases are documented, and many are very rare. Howe
Progressive muscle weakness
+
false
Joint tenderness
+
false
Muscle tenderness
+
false
Difficulty swallowing
+
false
Difficulty speaking
+
false
Fatigue
+
false
Shortness of breath
+
false
Weakness
+
false
Tenderness
+
false
@@ -16621,48 +17501,56 @@ There are other forms of uveitis that can be autoimmune.
Floaters in vision
+
false
Blurred vision
+
false
Eye pain
+
false
Sensitivity to light
+
false
Red eyes
+
false
Vision loss
+
false
Vision problems
+
false
Pain
+
false
@@ -16840,42 +17728,49 @@ Some patients experience full relief from symptoms with medical attention, while
Swollen joints
+
false
Pain, especially first thing in the morning or after a nap
+
false
Limping
+
false
Stiffness
+
false
Clumsiness, particularly in the morning or after naps
+
false
Swelling
+
false
Pain
+
false
@@ -16964,60 +17859,70 @@ Most papers on lichen planus assume all cases of the disease are autoimmune or d
Nail loss
+
false
Mouth ulcers
+
false
Blister inside mouth
+
false
White patches on gums
+
false
White patches on lips
+
false
Purplish, flat-topped bumps, on inner forearm, wrist or ankle, and sometimes on the genitals
+
false
Itching
+
false
Vaginal ulcers
+
false
Hair loss
+
false
Redness
+
false
@@ -17113,90 +18018,105 @@ Most papers on lichen planus assume all cases of the disease are autoimmune or d
Redness of anus
+
false
Pain during bowel movements
+
false
Easy bruising
+
false
Watery eyes
+
false
Abdominal cramps
+
false
Pain during sexual intercourse
+
false
Pain during urination
+
false
Blisters
+
false
Pain
+
false
Severe itching
+
false
Smooth white spots on skin
+
false
Discomfort, which is generally greater if lichen sclerosus appears on or around your genital or anal areas
+
false
Bleeding blisters
+
false
Nausea
+
false
Vomiting
+
false
@@ -17281,114 +18201,133 @@ Most papers on lichen planus assume all cases of the disease are autoimmune or d
Pain
+
false
Mouth ulcers
+
false
Watery eyes
+
false
Red eyes
+
false
Eye discharge
+
false
Eye pain
+
false
Sensitivity to light
+
false
Thickening of eyelid mucosa with a wood-like consistency
+
false
Fever
+
false
Ear pain
+
false
Hearing loss
+
false
Sore throat
+
false
Change in voice
+
false
Sores or masses under eyelid
+
false
Eye lesions
+
false
Eye irritation
+
false
Gum enlargement
+
false
Loss of teeth
+
false
Frequent infections
+
false
@@ -17607,102 +18546,119 @@ Most papers on lichen planus assume all cases of the disease are autoimmune or d
Burning
+
false
Blisters
+
false
Blister inside mouth
+
false
Mouth ulcers
+
false
Lip ulcers
+
false
Dry eyes
+
false
Sensitivity to light
+
false
Blister on lips
+
false
Blisters on skin
+
false
Itching
+
false
Patches of blisters
+
false
Burning skin
+
false
Eye irritation
+
false
Blurred vision
+
false
Scarring on cornea
+
false
Blindness
+
false
Vision problems
+
false
@@ -17807,156 +18763,182 @@ Most papers on lichen planus assume all cases of the disease are autoimmune or d
Chest pain
+
false
Difficulty swallowing
+
false
Constipation
+
false
Pain
+
false
Stiffness
+
false
Vomiting
+
false
Stiffness upon inactivity
+
false
Sleep problems
+
false
Concentration loss
+
false
Weight gain
+
false
Acid reflux/heartburn
+
false
Heavy menstrual flow
+
false
Prolonged menstrual bleeding
+
false
Painful, fatty lumps
+
false
Weakness
+
false
Fatigue
+
false
Depression
+
false
Epilepsy
+
false
Confusion
+
false
Irritability
+
false
Dementia
+
false
Migraine headaches
+
false
Memory problems
+
false
Rapid heartbeat
+
false
Joint pain
+
false
Shortness of breath
+
false
@@ -18067,198 +19049,231 @@ Most papers on lichen planus assume all cases of the disease are autoimmune or d
Pain
+
false
Swelling
+
false
Fever
+
false
Malaise
+
false
Weight loss
+
false
Fatigue
+
false
Swollen, painful nodule under skin
+
false
Itchy skin
+
false
Skin sores
+
false
Gangrene of extremities
+
false
Bluish coloring of hands/feet
+
false
Joint pain
+
false
Swollen joints
+
false
Cough
+
false
Shortness of breath
+
false
Heaviness in chest
+
false
Cramps
+
false
Abdominal pain
+
false
Bloating
+
false
Blood in stool
+
false
Vision loss
+
false
Blurred vision
+
false
Headache
+
false
Confusion
+
false
Seizures
+
false
Change in mental status
+
false
Hand pain
+
false
Foot pain
+
false
Weakness
+
false
Numbness
+
false
Tingling
+
false
Loss of sensation
+
false
Vision problems
+
false
@@ -18326,12 +19341,14 @@ The exact cause of both primary and secondary autoimmune orchitis is still unkno
Infertility
+
false
Unable to conceive
+
false
@@ -18421,54 +19438,63 @@ It is under debate whether collagenous and lymphocytic colitis are different pha
Pain
+
false
Diarrhea
+
false
Abdominal pain
+
false
Abdominal cramps
+
false
Abdominal bloating
+
false
Weight loss
+
false
Nausea
+
false
Loss of bowel control
+
false
Bowel movement urgency
+
false
@@ -18567,132 +19593,154 @@ It is under debate whether collagenous and lymphocytic colitis are different pha
Pain
+
false
Abnormal lumps below skin
+
false
Prickling sensations
+
false
Weight loss
+
false
Fever
+
false
Spitting up blood
+
false
Abdominal pain
+
false
Nausea
+
false
Vomiting
+
false
Diarrhea
+
false
Rash
+
false
Skin sores
+
false
Nerve pain
+
false
Weakness
+
false
Loss of sensation
+
false
Seizures
+
false
Difficulty breathing
+
false
Cough
+
false
Joint pain
+
false
Muscle pain
+
false
Tingling
+
false
Blood in stool
+
false
@@ -18795,102 +19843,119 @@ It is under debate whether collagenous and lymphocytic colitis are different pha
Pain
+
false
Stiffness
+
false
Facial pain
+
false
Weakness
+
false
Tightness of the skin of the fingers
+
false
Joint pain
+
false
Swollen hands
+
false
Stiffness of the skin of the fingers
+
false
Foot pain
+
false
Bluish coloring of hands/feet
+
false
Chest pain
+
false
Facial reddening
+
false
Butterfly-shaped rash face that covers the cheeks and bridge of the nose
+
false
Rash
+
false
Swelling
+
false
Butterfly-shaped rash
+
false
Yellow eyes
+
false
@@ -18981,66 +20046,77 @@ It is under debate whether collagenous and lymphocytic colitis are different pha
Pain
+
false
Vision loss
+
false
Eye pain
+
false
Blindness
+
false
Red eyes
+
false
Eye inflammation
+
false
Watery eyes
+
false
Eye discharge
+
false
Sensitivity to light
+
false
Blurred vision
+
false
Vision problems
+
false
@@ -19149,108 +20225,126 @@ There is no cure for morphea, but treatments are available to manage symptoms.
Pain
+
false
Facial pain
+
false
Headache
+
false
Vision problems
+
false
Dry eyes
+
false
Eye pain
+
false
Joint pain
+
false
Muscle pain
+
false
Weakness
+
false
Oval-shaped patches
+
false
Red patches with light center
+
false
Hair loss
+
false
Decreased sweating
+
false
Fatigue
+
false
Carpal tunnel syndrome
+
false
Difficulty swallowing
+
false
Shortness of breath
+
false
Seizures
+
false
@@ -19397,54 +20491,63 @@ Although this rare disease most commonly affects children, adults may have this
Headache
+
false
Weakness
+
false
Involuntary movements
+
false
Recurrent transient ischemic attacks
+
false
Seizures
+
false
Disturbed consciousness
+
false
Vision problems
+
false
Cognitive impairment
+
false
Sensory impairment
+
false
@@ -19572,114 +20675,133 @@ Although this rare disease most commonly affects children, adults may have this
Burning
+
false
Vision problems
+
false
Loss of bowel control
+
false
Unsteady gait
+
false
Weakness
+
false
Impaired coordination
+
false
Numbness
+
false
Eye pain
+
false
Pain
+
false
Vision loss
+
false
Tremor
+
false
Burning sensation
+
false
Tingling
+
false
Electric-shock sensations that occur with certain head movements
+
false
Double vision, horizontal or vertical, that improves when one eye is closed
+
false
Fatigue
+
false
Dizziness
+
false
Difficulty speaking
+
false
Double vision
+
false
@@ -19787,84 +20909,98 @@ Although this rare disease most commonly affects children, adults may have this
Weakness
+
false
Double vision, horizontal or vertical, that improves when one eye is closed
+
false
Difficulty swallowing
+
false
Difficulty chewing
+
false
Change in facial expression
+
false
Shortness of breath
+
false
Difficulty speaking
+
false
Vision problems
+
false
Weakness in hands
+
false
Weakness in arms
+
false
Eyelid drooping
+
false
Weakness in neck
+
false
Weakness in fingers
+
false
Double vision
+
false
@@ -19955,72 +21091,84 @@ Although this rare disease most commonly affects children, adults may have this
Pain
+
false
Weakness
+
false
Weakness in arms
+
false
Weakness in legs
+
false
Vision loss
+
false
Eye pain
+
false
Blurred vision
+
false
Difficulty seeing color
+
false
Back pain
+
false
Seizures
+
false
Loss of sensation
+
false
Vision problems
+
false
@@ -20114,54 +21262,63 @@ Although this rare disease most commonly affects children, adults may have this
Flu-like symptoms
+
false
Chest pain
+
false
Fatigue
+
false
Swelling
+
false
Shortness of breath
+
false
Pain
+
false
Rapid heartbeat
+
false
Irregular heartbeat
+
false
Lightheadedness
+
false
@@ -20259,60 +21416,70 @@ Although this rare disease most commonly affects children, adults may have this
Muscle pain
+
false
Difficulty swallowing
+
false
Weakness
+
false
Trouble rising from a chair
+
false
Pain
+
false
Weakness in arms
+
false
Tired feeling after standing or walking
+
false
Muscle soreness
+
false
Difficulty breathing
+
false
Difficulty climbing stairs
+
false
@@ -20405,108 +21572,126 @@ The specific location of vasculitis inflammation determines what tissue or organ
Weakness
+
false
skin sores
+
false
Nosebleeds
+
false
Fever
+
false
Chills
+
false
Fatigue
+
false
Weight loss
+
false
Redness
+
false
Pain
+
false
Tingling
+
false
Different sized pupils
+
false
Eyelid drooping
+
false
Difficulty swallowing
+
false
Movement difficulty
+
false
Cough
+
false
Shortness of breath
+
false
Nasal congestion
+
false
Coughing up blood
+
false
@@ -20652,42 +21837,49 @@ The specific location of vasculitis inflammation determines what tissue or organ
Joint pain
+
false
High shoulder blade
+
false
Reduced reflexes
+
false
Weakness
+
false
Prickling sensations
+
false
Pain
+
false
Winged shoulder blade
+
false
@@ -20785,48 +21977,56 @@ The specific location of vasculitis inflammation determines what tissue or organ
Eye pain
+
false
Vision loss
+
false
Paralysis
+
false
Hiccups
+
false
Nausea
+
false
Vomiting
+
false
Pain
+
false
Vision problems
+
false
@@ -20925,126 +22125,147 @@ The specific location of vasculitis inflammation determines what tissue or organ
Reduced reflexes
+
false
Hand spasms
+
false
Personality changes
+
false
Rapid heartbeat
+
false
Sleep problems
+
false
Memory problems
+
false
Muscle spasms
+
false
Feet spasms
+
false
Hallucinations
+
false
Confusion
+
false
Muscle stiffness
+
false
Cramps
+
false
Delayed muscle relaxation after strong contraction
+
false
Muscle pain
+
false
Muscle loss
+
false
Increased calf muscle size
+
false
Constipation
+
false
Psychosis
+
false
Weight loss
+
false
Pain
+
false
Stiffness
+
false
@@ -21142,78 +22363,91 @@ The specific location of vasculitis inflammation determines what tissue or organ
Sleep problems
+
false
Anxiety
+
false
Bedwetting
+
false
Behavioral changes
+
false
Deterioration in school performance
+
false
Sensory impairment
+
false
Depression
+
false
Aggression
+
false
Tics
+
false
Ocd
+
false
Irritability
+
false
Increased urination
+
false
Development regression
+
false
@@ -21308,78 +22542,91 @@ The specific location of vasculitis inflammation determines what tissue or organ
Skin discoloration
+
false
Frequent infections
+
false
Muscle cramps
+
false
Numbness
+
false
Tingling
+
false
Seizures
+
false
Fatigue
+
false
Abdominal pain
+
false
Dizziness
+
false
Weight loss
+
false
Hyperpigmentation
+
false
Hair loss
+
false
Pain
+
false
@@ -21487,96 +22734,112 @@ The specific location of vasculitis inflammation determines what tissue or organ
Cold intolerance
+
false
Eyelid drooping
+
false
Blurred vision
+
false
Swelling in neck
+
false
Fatigue
+
false
Nausea
+
false
Vomiting
+
false
Weakness
+
false
Anorexia
+
false
Dull facial expression
+
false
Swelling around eyes
+
false
Memory problems
+
false
Swelling
+
false
Vision problems
+
false
Weight loss
+
false
Poor skin rigidity
+
false
@@ -21663,84 +22926,98 @@ The specific location of vasculitis inflammation determines what tissue or organ
Skin texture changes
+
false
Eyelid drooping
+
false
Hunger
+
false
Skin pigmentation loss
+
false
Alopecia
+
false
Fatigue
+
false
Puffy face
+
false
Weakness
+
false
Blurred vision
+
false
Weight loss
+
false
Shortness of breath
+
false
Swelling
+
false
Vision problems
+
false
Swelling in neck
+
false
@@ -21823,126 +23100,147 @@ The specific location of vasculitis inflammation determines what tissue or organ
Hunger
+
false
Loss of bowel control
+
false
Increased frequency of urination
+
false
Bowel movement urgency
+
false
Scaling of the scalp
+
false
Increased thirst
+
false
Weight loss
+
false
Mood changes
+
false
Fatigue
+
false
Weakness
+
false
Blurred vision
+
false
Diarrhea
+
false
Blood in stool
+
false
Rectal bleeding
+
false
Fever
+
false
Skin pigmentation loss
+
false
Pain
+
false
Joint stiffness
+
false
Yellow skin
+
false
Stiffness
+
false
Vision problems
+
false
@@ -22029,84 +23327,98 @@ The specific location of vasculitis inflammation determines what tissue or organ
Shoulder pain
+
false
Weight loss
+
false
Wrist pain
+
false
Knee stiffness
+
false
Wrist stiffness
+
false
Fever
+
false
Malaise
+
false
Knee pain
+
false
Stiffness upon inactivity
+
false
Muscle pain
+
false
Limited range of motion in affected areas
+
false
Fatigue
+
false
Stiffness
+
false
Pain
+
false
@@ -22207,90 +23519,105 @@ The specific location of vasculitis inflammation determines what tissue or organ
Difficulty speaking
+
false
Fatigue
+
false
Difficulty swallowing
+
false
Pain
+
false
Shortness of breath
+
false
Weakness
+
false
Difficulty breathing
+
false
Weight loss
+
false
Muscle pain
+
false
Difficulty moving from sitting to standing
+
false
Falling
+
false
Difficulty climbing stairs
+
false
Weakness in joints
+
false
Joint pain
+
false
Fever
+
false
@@ -22405,108 +23732,126 @@ The specific location of vasculitis inflammation determines what tissue or organ
Fatigue
+
false
Itchy skin
+
false
Dry eyes
+
false
Dry mouth
+
false
Joint pain
+
false
Muscle pain
+
false
Bone pain
+
false
Swollen feet
+
false
Swollen ankles
+
false
Accumulation of fluid in the abdomen
+
false
Fatty deposits on the skin around your eyes, your eyelids, or in the creases in your palms, soles, elbows or knees
+
false
Yellow skin
+
false
Hyperpigmentation
+
false
Diarrhea
+
false
Weight loss
+
false
Swelling
+
false
Pain
+
false
Yellow eyes
+
false
@@ -22623,78 +23968,91 @@ The specific location of vasculitis inflammation determines what tissue or organ
Fatigue
+
false
Itchy skin
+
false
Abdominal discomfort
+
false
Abdominal pain
+
false
Malaise
+
false
Nausea
+
false
Fever
+
false
Chills
+
false
Night sweats
+
false
Weight loss
+
false
Dark urine
+
false
Pain
+
false
Yellow eyes
+
false
@@ -22789,18 +24147,21 @@ The development of psoriasis involves a complex cycle of immune activation and s
Small scaling spots
+
false
Dry, cracked skin that may bleed
+
false
Disorders of finger and toe nails
+
false
@@ -22898,84 +24259,98 @@ The development of psoriasis involves a complex cycle of immune activation and s
Swollen feet
+
false
Swollen ankles
+
false
Swollen hands
+
false
Joint pain
+
false
Swollen toes
+
false
Back pain
+
false
Stiffness
+
false
Fatigue
+
false
Swollen wrists
+
false
Swollen elbows
+
false
Swollen shoulders
+
false
Swollen knees
+
false
Swelling
+
false
Pain
+
false
@@ -23067,42 +24442,49 @@ Secondary Raynaud's is a symptom experienced (and reported) by patients with aut
Foot pain
+
false
Bluish coloring of hands/feet
+
false
Numbness
+
false
Pain
+
false
Coldness
+
false
Hand pain
+
false
When blood starts to return to these areas, fingers or toes that turn red, burn, throb, experience numbness, or tingle.
+
false
@@ -23204,108 +24586,126 @@ Secondary Raynaud's is a symptom experienced (and reported) by patients with aut
Burning
+
false
Joint pain
+
false
Joint stiffness
+
false
Tendon pain
+
false
Back pain
+
false
Eye irritation
+
false
Blurred vision
+
false
Sensitivity to light
+
false
Burning with urination
+
false
Increased frequency of urination
+
false
Diarrhea
+
false
Fever
+
false
Fatigue
+
false
Weight loss
+
false
Rash
+
false
Stiffness
+
false
Pain
+
false
Vision problems
+
false
@@ -23413,96 +24813,112 @@ In cases where the cartilage is not visible, RP can cause heart valve abnormalit
Fatigue
+
false
Fever
+
false
Ear pain
+
false
Limpness of the ear
+
false
Loss of hearing
+
false
Dizziness
+
false
Rib pain
+
false
Joint pain
+
false
Nasal congestion
+
false
Nosebleeds
+
false
Wheezing
+
false
Shortness of breath
+
false
Cough
+
false
Hoarseness
+
false
High-pitched sound during breathing
+
false
Pain
+
false
@@ -23588,18 +25004,21 @@ In cases where the cartilage is not visible, RP can cause heart valve abnormalit
Discomfort in legs that is relieved by movement
+
false
Discomfort in legs that occur mainly at night
+
false
Discomfort in legs that begins after lying down or sitting for a long time
+
false
@@ -23703,114 +25122,133 @@ The severity of cases may vary, with mild cases resolving in under a year and se
Difficulty concentrating
+
false
Personality changes
+
false
Depression
+
false
Psychosis
+
false
Aggression
+
false
Anxiety
+
false
Muscle pain
+
false
Dark spots in vision
+
false
Loss of peripheral vision
+
false
Hearing loss
+
false
Ringing in ears
+
false
Dizziness
+
false
Difficulty speaking
+
false
Unsteady gait
+
false
Migraine headaches
+
false
Memory problems
+
false
Confusion
+
false
Pain
+
false
Vision problems
+
false
@@ -23900,72 +25338,84 @@ Since antibiotics have reduced the incidence of rheumatic fever, the incidence o
Unsteady gait
+
false
Mood changes
+
false
Involuntary movements
+
false
Difficulty speaking
+
false
Weakness
+
false
Difficulty concentrating
+
false
Obsessions
+
false
Compulsive behavior
+
false
Anxiety
+
false
Confusion
+
false
Irritability
+
false
Difficulty walking
+
false
@@ -24072,96 +25522,112 @@ Note: scarlet fever is another symptom of a strep infection but is not a separat
Pain
+
false
Involuntary movements
+
false
Behavioral changes
+
false
Joint pain
+
false
Abnormal lumps below skin
+
false
Swollen joints
+
false
Joint tenderness
+
false
Migrating joint pain
+
false
Fever
+
false
Chest pain
+
false
Heart murmur
+
false
Fatigue
+
false
Flat or slightly raised, painless rash with a ragged edge
+
false
Swelling
+
false
Rash
+
false
Tenderness
+
false
@@ -24289,72 +25755,84 @@ There is no cure, though treatments to manage symptoms are available. Prognosis
Pain
+
false
Joint pain
+
false
Stiffness
+
false
Swollen joints
+
false
Tenderness
+
false
Nodules in fingers
+
false
Nodules in heel
+
false
Nodules in toes
+
false
Fatigue
+
false
Fever
+
false
Weight loss
+
false
Firm bumps of tissue under the skin on your arms
+
false
@@ -24367,12 +25845,14 @@ There is no cure, though treatments to manage symptoms are available. Prognosis
Carpal tunnel syndrome
+
false
Swelling
+
false
@@ -24468,90 +25948,105 @@ There is no cure, though treatments to manage symptoms are available. Prognosis
Pain
+
false
Vision problems
+
false
Finger pain
+
false
Toe pain
+
false
Tingling
+
false
Numbness
+
false
Eye pain
+
false
Chest pain
+
false
Shortness of breath
+
false
Fever
+
false
Weight loss
+
false
Rash
+
false
skin sores
+
false
Blood in stool
+
false
Blood in urine
+
false
@@ -24659,162 +26154,189 @@ Sarcoidosis often starts with a set of symptoms collectively referred to as Lofg
Pain
+
false
Swelling
+
false
Weakness
+
false
Vision problems
+
false
Weakness in facial muscles
+
false
Swollen legs
+
false
Irregular heartbeat
+
false
Weakness in arms
+
false
Eye pain
+
false
Chest pain
+
false
Weakness in legs
+
false
Shortness of breath
+
false
Wheezing
+
false
Fatigue
+
false
Weight loss
+
false
Night sweats
+
false
Skin discoloration
+
false
Scaly-appearing skin
+
false
Rash
+
false
Muscle pain
+
false
Red eyes
+
false
Sensitivity to light
+
false
Blurred vision
+
false
Cough
+
false
Fever
+
false
Joint pain
+
false
Headache
+
false
@@ -24894,48 +26416,56 @@ Patients with Schnitzler syndrome typically experience chronic rash, relapsing f
Pain
+
false
Muscle pain
+
false
Fever
+
false
Joint pain
+
false
Fatigue
+
false
Weight loss
+
false
Bone pain
+
false
Rash
+
false
@@ -25026,60 +26556,70 @@ Patients with Schnitzler syndrome typically experience chronic rash, relapsing f
Pain
+
false
Vision problems
+
false
Eye pain
+
false
Headache
+
false
Vision loss
+
false
Watery eyes
+
false
Blurred vision
+
false
Sensitivity to light
+
false
Eye irritation
+
false
Double vision
+
false
@@ -25208,156 +26748,182 @@ Patients with Schnitzler syndrome typically experience chronic rash, relapsing f
Cognitive impairment
+
false
Sinus infection
+
false
Dry mouth
+
false
Rash
+
false
Burning
+
false
Joint stiffness
+
false
Swollen joints
+
false
Pain
+
false
Dry eyes
+
false
Bluish coloring of hands/feet
+
false
Foot pain
+
false
Sinus inflammation
+
false
Swelling of salivary glands
+
false
Fatigue
+
false
Burning/gritty sensation in eyes
+
false
Acid reflux/heartburn
+
false
Shortness of breath
+
false
Depression
+
false
Anxiety
+
false
Dizziness
+
false
Cough
+
false
Stiffness
+
false
Swelling
+
false
Hand pain
+
false
Dry skin
+
false
Vaginal dryness
+
false
@@ -25473,114 +27039,133 @@ Patients with Schnitzler syndrome typically experience chronic rash, relapsing f
Skin sores
+
false
Swollen hands
+
false
Nose ulcers
+
false
Swollen legs
+
false
Mouth rash
+
false
Swollen feet
+
false
Nose rash
+
false
Swollen ankles
+
false
Swelling
+
false
Rash
+
false
Foamy, frothy urine
+
false
Headache
+
false
Dizziness
+
false
Nausea
+
false
Vomiting
+
false
Weight gain
+
false
Increased urination at night
+
false
Blood in urine
+
false
Mouth ulcers
+
false
@@ -25765,192 +27350,224 @@ Patients with Schnitzler syndrome typically experience chronic rash, relapsing f
Psychosis
+
false
Disorientation
+
false
Cognitive impairment
+
false
Headache
+
false
Memory problems
+
false
Impaired coordination
+
false
Difficulty understanding basic concepts
+
false
Difficulty retaining information
+
false
Difficulty finding words
+
false
Attention-span problems
+
false
Anxiety
+
false
Confusion
+
false
Altered level of consciousness
+
false
Behavioral changes
+
false
Coma
+
false
Depression
+
false
Sleep problems
+
false
Fever
+
false
Seizure during which the person remains conscious and alert
+
false
Seizure during which the person remains unconscious
+
false
Hallucinations
+
false
Over-responsive reflexes
+
false
Prone to infections
+
false
Irritability
+
false
Nausea
+
false
Paralysis
+
false
Paranoid delusions
+
false
Personality changes
+
false
Daytime sleepiness
+
false
Fatigue
+
false
Social withdrawal
+
false
Vomiting
+
false
@@ -26047,66 +27664,77 @@ Patients with Schnitzler syndrome typically experience chronic rash, relapsing f
Pain
+
false
Stiffness
+
false
Back pain
+
false
Lower back stiffness
+
false
Muscle spasms
+
false
Unsteady gait
+
false
Leg stiffness
+
false
Hunched posture
+
false
Anxiety
+
false
Weight loss
+
false
Feeling full quickly after eating
+
false
@@ -26202,72 +27830,84 @@ This condition most frequently occurs following surgery to a region of the body
Pain
+
false
Chest pain
+
false
Rapid heartbeat
+
false
Abdominal pain
+
false
Fatigue
+
false
Shortness of breath
+
false
Fever
+
false
Heart palpitations
+
false
Weakness
+
false
Weight loss
+
false
Irritability
+
false
Joint pain
+
false
@@ -26363,72 +28003,84 @@ This condition most frequently occurs following surgery to a region of the body
Pain
+
false
Vision problems
+
false
Floaters in vision
+
false
Skin pigmentation loss
+
false
Eye pain
+
false
Red eyes
+
false
Blurred vision
+
false
Sensitivity to light
+
false
Watery eyes
+
false
Blindness
+
false
Hearing loss
+
false
Headache
+
false
@@ -26545,96 +28197,112 @@ This condition most frequently occurs following surgery to a region of the body
Pain
+
false
Swelling
+
false
Rash
+
false
Stiffness
+
false
Joint pain
+
false
Bluish coloring of hands/feet
+
false
Chest pain
+
false
Joint stiffness
+
false
Swollen joints
+
false
Fatigue
+
false
Fever
+
false
Butterfly-shaped rash face that covers the cheeks and bridge of the nose
+
false
Skin lesions that appear or worsen with sun exposure
+
false
Shortness of breath
+
false
Dry eyes
+
false
Butterfly-shaped rash
+
false
@@ -26717,96 +28385,112 @@ When mastocytosis is limited to the skin, it is called cutaneous mastocytosis, a
Pain
+
false
Mood changes
+
false
Headache
+
false
Lightheadedness
+
false
Dizziness
+
false
Nausea
+
false
Bone pain
+
false
Muscle pain
+
false
Fatigue
+
false
Nasal congestion
+
false
Shortness of breath
+
false
Depression
+
false
Concentration loss
+
false
Itching
+
false
Abdominal pain
+
false
Diarrhea
+
false
@@ -26923,120 +28607,140 @@ When mastocytosis is limited to the skin, it is called cutaneous mastocytosis, a
Pain
+
false
Muscle pain
+
false
Weakness
+
false
Finger pain
+
false
Toe pain
+
false
Joint pain
+
false
Swollen joints
+
false
Chest pain
+
false
Fatigue
+
false
Dry eyes
+
false
Dry mouth
+
false
Dry cough
+
false
Shortness of breath
+
false
Acid reflux/heartburn
+
false
Diarrhea
+
false
Weight loss
+
false
Itching
+
false
Constipation
+
false
Difficulty swallowing
+
false
Swelling
+
false
@@ -27158,108 +28862,126 @@ To be diagnosed with CREST, you must have 3 out of the 5 symptoms.
Pain
+
false
Swelling
+
false
Hand pain
+
false
Vision problems
+
false
Bluish coloring of hands/feet
+
false
Foot pain
+
false
Difficulty breathing
+
false
Abdominal discomfort
+
false
Nausea
+
false
Vomiting
+
false
Empty feeling in the abdomen/stomach
+
false
Tightness in the abdomen
+
false
Churning in the stomach
+
false
“butterflies” in the stomach
+
false
Acid reflux/heartburn
+
false
Abdominal pain
+
false
Hunger
+
false
Difficulty swallowing
+
false
@@ -27358,42 +29080,49 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
Fatigue
+
false
Fever
+
false
Night sweats
+
false
Weight loss
+
false
Muscle pain
+
false
Joint pain
+
false
Headache
+
false
@@ -27401,23 +29130,27 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
false
Lightheadedness
+
false
Arm weakness
+
Chest pain
+
false
Shortness of breath
+
false
@@ -27425,23 +29158,27 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
false
Fainting
+
Blurred vision
+
false
Vision problems
+
false
Tingling of extremities
+
false
@@ -27550,36 +29287,42 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
Pain
+
false
Vision loss
+
false
Shoulder pain
+
false
Arm pain upon exertion
+
false
Hip pain
+
false
Weight loss
+
false
@@ -27598,78 +29341,91 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
Headache
+
false
Jaw pain when you open your mouth
+
false
Scalp tenderness
+
false
Fever
+
false
Fatigue
+
false
Double vision
+
false
Blurred vision
+
false
Cough
+
false
Throat pain
+
false
Tongue pain
+
false
Depression
+
false
Vision problems
+
false
Tenderness
+
false
@@ -27805,30 +29561,35 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
Pain
+
false
Constant pain behind the eye
+
false
Headache
+
false
Double vision
+
false
Vision problems
+
false
@@ -27941,162 +29702,189 @@ Early symptoms may include fever, night sweats, fatigue, joint pain, and chest d
Pain
+
false
Burning
+
false
Sensory impairment
+
false
Weakness in arms
+
false
Abnormal bladder control
+
false
Numbness
+
false
Coldness
+
false
Weakness in legs
+
false
Burning sensation
+
false
Partial paralysis of the legs
+
false
Total paralysis of the legs
+
false
Muscle pain
+
false
Muscle spasms
+
false
Increased frequency of urination
+
false
Difficulty urinating
+
false
Constipation
+
false
Sensitivity to extreme heat
+
false
Sensitivity to extreme cold
+
false
Headache
+
false
Fever
+
false
Depression
+
false
Anxiety
+
false
Painful and decreased eye movements
+
false
Double vision
+
false
Fatigue
+
false
Weakness
+
false
Vision problems
+
false
@@ -28201,90 +29989,105 @@ Both UC and CD are caused by an autoimmune response that reflects the involvemen
Pain
+
false
Abdominal pain
+
false
Blood in stool
+
false
Joint pain
+
false
Skin sores
+
false
Urgency without having a bowel movement
+
false
Rectal pain
+
false
Abdominal cramps
+
false
Fever
+
false
Constipation
+
false
Weight loss
+
false
Fatigue
+
false
Dehydration
+
false
Stunted growth in children
+
false
Diarrhea
+
false
@@ -28393,114 +30196,133 @@ Both UC and CD are caused by an autoimmune response that reflects the involvemen
Pain
+
false
Hand pain
+
false
Weakness
+
false
Seizures
+
false
Foot pain
+
false
Bluish coloring of hands/feet
+
false
Chest pain
+
false
Dry eyes
+
false
Dry mouth
+
false
Joint pain
+
false
Butterfly-shaped rash face that covers the cheeks and bridge of the nose
+
false
Hair loss
+
false
Interstitial pneumonia
+
false
Mental disorders
+
false
Sensitivity to light
+
false
Fatigue
+
false
Mouth ulcers
+
false
Rash
+
false
Butterfly-shaped rash
+
false
@@ -28597,108 +30419,126 @@ Urticaria can also be caused by allergic reaction to plants like poison ivy, dye
Burning
+
false
Muscle pain
+
false
Skin discoloration
+
false
Joint pain
+
false
Cough
+
false
Raised purple-red spots
+
false
Pain
+
false
Burning sensation
+
false
Fluid-dilled sacs
+
false
Bumps on skin containing pus
+
false
Abnormal lumps below skin
+
false
Crusted ulcers
+
false
Fever
+
false
Weight loss
+
false
Abdominal pain
+
false
Vomiting
+
false
Weakness
+
false
Rash
+
false
@@ -28807,48 +30647,56 @@ The most common form of autoimmune uveitis is intermediate uveitis.
Pain
+
false
Blurred vision
+
false
Sensitivity to light
+
false
Eye pain
+
false
Floaters in vision
+
false
Headache
+
false
Red eyes
+
false
Vision problems
+
false
@@ -28949,30 +30797,35 @@ Normally, the color of hair, skin, and eyes is determined by melanin. Vitiligo o
Premature whitening or graying of the hair on your scalp, eyelashes, eyebrows or beard
+
false
Skin discoloration
+
false
Loss of color in the tissues that line the inside of your mouth
+
false
Loss of or change in color of the inner layer of your eye
+
false
Milky white patches on skin
+
false
@@ -29065,72 +30918,84 @@ Normally, the color of hair, skin, and eyes is determined by melanin. Vitiligo o
Pain
+
false
Headache
+
false
Skin pigmentation loss
+
false
Yellow skin
+
false
Eye pain
+
false
Dizziness
+
false
Nausea
+
false
Eye inflammation
+
false
Blurred vision
+
false
Hearing loss
+
false
Hair loss
+
false
Vision problems
+
false
@@ -29224,66 +31089,77 @@ Some cases of this disease are caused by medications and are not autoimmune.
Pain
+
false
Weakness
+
false
Muscle pain
+
false
Fatigue
+
false
Difficulty breathing
+
false
Shortness of breath
+
false
Headache
+
false
Dizziness
+
false
Rapid heartbeat
+
false
Chills
+
false
Yellow eyes
+
false
@@ -30818,372 +32694,434 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Double vision
+
false
Sensitivity to light
+
false
Corneal ulceration
+
false
Vision problems
+
false
Forward displacement of eye
+
false
Eye irritation
+
false
Dry eyes
+
false
Watery eyes
+
false
Vision loss
+
false
Inability to move the eye
+
false
Anxiety in children
+
false
Muscle spasms
+
false
Irritability in children
+
false
Rage attacks
+
false
Unsteady gait
+
false
Fast, irregular eye movements
+
false
Brain fog
+
false
Fatigue
+
false
Sleep problems
+
false
Weakness
+
false
Impaired coordination
+
false
Stiffness
+
false
Restricted mobility
+
false
Swelling
+
false
Pain
+
false
Swollen joints
+
false
Tendon pain
+
false
Fever
+
false
Joint stiffness
+
false
Fatigue
+
false
Joint pain
+
false
Dizziness
+
false
Nausea
+
false
Hand tremor
+
false
Memory problems
+
false
Tremor
+
false
Involuntary movements
+
false
Difficulty speaking
+
false
Unsteady gait
+
false
Double vision
+
false
Vision problems
+
false
Fast, irregular eye movements
+
false
Vertigo
+
false
Difficulty swallowing
+
false
Impaired coordination
+
false
Fatigue
+
false
Erectile dysfunction
+
false
Headache
+
false
Shortness of breath
+
false
Pain
+
false
Irregular heartbeat
+
false
Trouble breathing when you exercise
+
false
Muscle spasms
+
false
Abdominal pain
+
false
Dark urine
+
false
Genital blisters
+
false
Blister inside throat
+
false
Blisters
+
false
Pain
+
false
Causes blisters on the chest, back and shoulders
+
false
Skin blisters
+
false
Blisters are painful but do not itch
+
false
@@ -31196,504 +33134,588 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Blisters that rupture easily, leaving open sores, which may ooze and become infected.
+
false
Blister inside mouth
+
false
Itchy blisters
+
false
Skin hardening
+
false
Weakness
+
false
Progressive weakness in the legs
+
false
Skin discoloration
+
false
Problems with metabolism
+
false
Excessive sweating
+
false
Vision problems
+
false
Fatigue
+
false
Progressive weakness in the arms
+
false
Vomiting
+
false
Coldness
+
false
Fatigue
+
false
Weight loss
+
false
Joint pain
+
false
Night sweats
+
false
Pain
+
false
Vision problems
+
false
Fever
+
false
Weakness
+
false
Rash
+
false
Vision loss
+
false
Abdominal pain
+
false
Nausea
+
false
Muscle pain
+
false
Chest pain
+
false
Heart palpitations
+
false
Rapid heartbeat
+
false
Shortness of breath
+
false
Difficulty breathing
+
false
Fever
+
false
Irritability
+
false
Pain
+
false
Joint pain
+
false
Fatigue
+
false
Shortness of breath
+
false
Swelling
+
false
Fatigue
+
false
Difficulty exercising
+
false
Pain
+
false
Chest pain
+
false
Weight gain
+
false
Heart palpitations
+
false
Misalignment of teeth
+
false
Skin discoloration
+
false
Absence of eyelashes
+
false
Burning sensation
+
false
Misalignment of jaw
+
false
Whitening of hair
+
false
Curling of upper lip
+
false
Prickling sensations
+
false
Eyelid drooping
+
false
Burning
+
false
Difficulty chewing
+
false
Backwards displacement of eye
+
false
Pain
+
false
Migraine headaches
+
false
Difficulty moving jaw
+
false
Different colored eyes
+
false
Facial pain
+
false
Skull depressions
+
false
Seizures
+
false
Bald patches
+
false
Thinning or shrinking of facial tissues
+
false
Dizziness
+
false
Fatigue
+
false
Difficulty breathing
+
false
Shortness of breath
+
false
Easy bruising
+
false
Fever
+
false
Pain
+
false
Skin sores
+
false
Joint pain
+
false
Muscle pain
+
false
Small red bumps
+
false
Loss of motor skills
+
false
Vision problems
+
false
Weakness
+
false
Mental decline
+
false
Seizures
+
false
Paralysis
+
false
Progressive loss of speech
+
false
@@ -31755,6 +33777,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Acute/subacute limbic amnesia and confusion
+
85–95%
false
@@ -31762,6 +33785,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Marked psychiatric and behavioral changes (agitation, psychosis)
+
65–80%
false
@@ -31769,6 +33793,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Epileptic seizures
+
50–60%
false
@@ -31828,6 +33853,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Early intractable limbic seizures and temporal lobe status
+
90–100%
false
@@ -31835,6 +33861,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe short-term memory loss / amnesia
+
80–90%
false
@@ -31842,6 +33869,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Behavioral changes, confusion, and psychosis
+
60–70%
false
@@ -31918,6 +33946,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe aortic valve regurgitation
+
40–55%
false
@@ -31925,6 +33954,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Deep thoracic or back pain
+
40–50%
false
@@ -31997,6 +34027,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe, intractable, chronic secretory diarrhea persisting during fasting
+
95–100%
false
@@ -32011,6 +34042,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe malabsorption, cachexia, and involuntary weight loss
+
85–95%
false
@@ -32018,6 +34050,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Protein-losing enteropathy with severe hypoalbuminemia and anasarca
+
60–75%
false
@@ -32092,6 +34125,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Progressive dysphagia to both liquids and solids
+
90–100%
false
@@ -32099,6 +34133,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Regurgitation of undigested, retained food
+
75–85%
false
@@ -32106,6 +34141,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Retrosternal crampy chest pain
+
50–65%
false
@@ -32113,6 +34149,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Significant weight loss
+
50–60%
false
@@ -32120,6 +34157,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Nocturnal cough and pulmonary aspiration
+
30–40%
false
@@ -32186,6 +34224,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Meningoencephalitis symptoms: subacute fever, severe headache, and neck stiffness
+
75–85%
false
@@ -32193,6 +34232,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Encephalopathy, confusion, and delirium
+
65–75%
false
@@ -32200,6 +34240,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Myelopathy with spinal paraparesis and sensory deficit
+
40–50%
false
@@ -32207,6 +34248,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autonomic dysregulation and neurogenic bladder
+
35–45%
false
@@ -32214,6 +34256,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Visual impairment / bilateral optic disc edema (papillitis)
+
30–40%
false
@@ -32278,6 +34321,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Spontaneous, extensive subcutaneous and soft-tissue hematomas
+
80–90%
false
@@ -32285,6 +34329,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Prolonged, unprovoked post-traumatic or post-surgical hemorrhage
+
70–85%
false
@@ -32292,6 +34337,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Mucocutaneous, hematuric, and gastrointestinal bleeding
+
25–35%
false
@@ -32299,6 +34345,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Spontaneous hemarthrosis
+
<10%
false
@@ -32378,6 +34425,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rapidly progressive, symmetric sensorimotor polyradiculoneuropathy
+
85–95%
false
@@ -32392,6 +34440,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe sensory ataxia with gait failure
+
60–75%
false
@@ -32399,6 +34448,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe quadriparesis / motor disability
+
50–65%
false
@@ -32406,6 +34456,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Marked high-amplitude postural and action tremor
+
40–50%
false
@@ -32467,6 +34518,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Generalized areflexia
+
90–95%
false
@@ -32474,6 +34526,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Subacute to acute severe symmetrical distal and proximal limb weakness
+
80–90%
false
@@ -32481,6 +34534,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe proprioceptive sensory ataxia and positive Romberg sign
+
70–80%
false
@@ -32488,6 +34542,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Prominent action tremor of hands and arms
+
40–55%
false
@@ -32554,6 +34609,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Microangiopathic hemolytic anemia with schistocytes on blood smear
+
95–100%
false
@@ -32561,6 +34617,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Profound consumptive thrombocytopenia with purpura and bleeding
+
95–100%
false
@@ -32568,6 +34625,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Fluctuating neurological symptoms (confusion, transient focal deficits, seizure, coma)
+
60–70%
false
@@ -32575,6 +34633,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Renal dysfunction (azotemia, proteinuria, hematuria)
+
40–50%
false
@@ -32582,6 +34641,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Low-grade fever
+
25–35%
false
@@ -32641,6 +34701,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Inability to conceive after ≥1 year of unprotected intercourse with normal evaluations
+
95–100%
false
@@ -32710,6 +34771,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Recurrent episodes of severe hypersomnia (sleeping 16–20 hours daily for days/weeks)
+
100%
false
@@ -32724,6 +34786,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Cognitive derealization, apathy, and altered perception
+
80–90%
false
@@ -32731,6 +34794,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Compulsive megaphagia / binge eating during episodes
+
70–80%
false
@@ -32738,6 +34802,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypersexuality and disinhibited behaviors
+
45–55%
false
@@ -32800,6 +34865,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Early-onset multi-organ autoimmunity starting in infancy/childhood
+
100%
false
@@ -32807,6 +34873,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune cytopenias (autoimmune thrombocytopenia, AIHA, neutropenia)
+
70–80%
false
@@ -32814,6 +34881,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Postnatal growth failure and severe short stature
+
60–75%
false
@@ -32821,6 +34889,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic lymphadenopathy and hepatosplenomegaly
+
50–60%
false
@@ -32828,6 +34897,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Early-onset type 1 diabetes mellitus
+
40–50%
false
@@ -32835,6 +34905,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe chronic autoimmune enteropathy with intractable diarrhea
+
40–50%
false
@@ -50893,6 +52964,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Disseminated non-tuberculous mycobacterial (NTM) infections
+
80–90%
false
@@ -50900,6 +52972,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic suppurative lymphadenitis
+
65–75%
false
@@ -50907,6 +52980,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Reactive pustular/neutrophilic dermatoses (Sweet-like)
+
40–50%
false
@@ -50914,6 +52988,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Opportunistic fungal infections (cryptococcosis, penicilliosis)
+
30–40%
false
@@ -51131,6 +53206,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe neuropathic pain
+
60–70%
false
@@ -51138,6 +53214,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Peripheral nerve hyperexcitability (myokymia, fasciculations, muscle cramps)
+
50–60%
false
@@ -51145,6 +53222,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Limbic encephalitis with cognitive decline
+
40–50%
false
@@ -51152,6 +53230,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe agrypnia / intractable insomnia (Morvan syndrome)
+
30–40%
false
@@ -51194,6 +53273,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Prodromal severe diarrhea and weight loss
+
80–90%
false
@@ -51201,6 +53281,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
CNS hyperexcitability: hyperekplexia (exaggerated startle), myoclonus, tremor
+
70–80%
false
@@ -51208,6 +53289,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Progressive cognitive impairment and amnesia
+
60–70%
false
@@ -51250,6 +53332,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Refractory status epilepticus / frequent multifocal seizures
+
85–95%
false
@@ -51257,6 +53340,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rapid cognitive and behavioral decline
+
60–70%
false
@@ -51264,6 +53348,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Movement disorders (chorea, catatonia, opsoclonus)
+
30–40%
false
@@ -51376,6 +53461,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Prominent sleep architecture disruption (NREM parasomnia, sleep apnea, stridor)
+
80–90%
false
@@ -51383,6 +53469,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Bulbar dysfunction (dysphagia, dysarthria, vocal cord palsy)
+
60–70%
false
@@ -51390,6 +53477,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Progressive gait instability and ataxia
+
50–65%
false
@@ -51397,6 +53485,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chorea, dystonia, or abnormal ocular movements
+
30–40%
false
@@ -51439,6 +53528,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rapidly progressive short-term memory impairment
+
85–90%
false
@@ -51446,6 +53536,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Pathognomonic faciobrachial dystonic seizures (FBDS)
+
60–75%
false
@@ -51453,6 +53544,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Refractory hyponatremia (SIADH-like)
+
60–70%
false
@@ -51460,6 +53552,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Psychiatric disturbances (confusion, paranoia, hallucinations)
+
60–70%
false
@@ -51502,6 +53595,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Distal lower limb numbness, paresthesias, and pain
+
90–100%
false
@@ -51509,6 +53603,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Slowly progressive, symmetric distal sensory ataxia
+
85–95%
false
@@ -51516,6 +53611,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Marked postural and action tremor of the hands
+
60–75%
false
@@ -51523,6 +53619,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Mild late distal motor weakness (foot drop)
+
40–50%
false
@@ -51565,6 +53662,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Gottron's papules / sign
+
80–95%
false
@@ -51572,6 +53670,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rapidly progressive interstitial lung disease with hypoxemic respiratory failure
+
75–90%
false
@@ -51579,6 +53678,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Painful deep cutaneous ulcerations (digital, knuckles, elbows)
+
60–80%
false
@@ -51593,6 +53693,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Palmar violaceous papules / inverse Gottron's
+
40–50%
false
@@ -51635,6 +53736,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe proximal symmetrical muscle weakness
+
85–95%
false
@@ -51642,6 +53744,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Gottron's papules
+
75–85%
false
@@ -51649,6 +53752,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Extensive subcutaneous calcinosis (calcinosis cutis)
+
40–60%
false
@@ -51656,6 +53760,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe dysphagia and neck flexor weakness
+
35–45%
false
@@ -51663,6 +53768,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Peripheral and periorbital subcutaneous edema
+
30–40%
false
@@ -51852,6 +53958,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic disabling fatigue and unrefreshing sleep
+
80–90%
false
@@ -51859,6 +53966,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Diffuse myalgias and muscle weakness
+
70–80%
false
@@ -51866,6 +53974,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Arthralgias or inflammatory arthritis
+
60–75%
false
@@ -51873,6 +53982,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Cognitive impairment, memory loss, and brain fog
+
50–60%
false
@@ -51915,6 +54025,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Microangiopathic hemolytic anemia with fragmented schistocytes
+
95–100%
false
@@ -51922,6 +54033,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe consumptive thrombocytopenia
+
90–95%
false
@@ -51929,6 +54041,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Acute oliguric renal failure / azotemia
+
85–95%
false
@@ -52048,6 +54161,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe, disabling orthostatic hypotension and syncope
+
90–100%
false
@@ -52055,6 +54169,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe gastrointestinal dysmotility (gastroparesis, pseudo-obstruction, constipation)
+
70–80%
false
@@ -52062,6 +54177,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Sicca syndrome (severe dry mouth and dry eyes)
+
70–80%
false
@@ -52069,6 +54185,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Tonic, unreactive, or poorly reactive pupils
+
60–75%
false
@@ -52076,6 +54193,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Anhidrosis / loss of sweating
+
60–70%
false
@@ -52083,6 +54201,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Neurogenic urinary retention
+
50–60%
false
@@ -52125,6 +54244,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Progressive gait instability and appendicular limb ataxia
+
90–100%
false
@@ -52132,6 +54252,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Cerebellar dysarthria / slurred scanning speech
+
70–85%
false
@@ -52139,6 +54260,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Nystagmus, saccadic intrusions, and ocular dysmetria
+
60–75%
false
@@ -52146,6 +54268,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Intention and action tremor
+
50–65%
false
@@ -52188,6 +54311,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Refractory extreme hypertriglyceridemia (>1,000–2,000 mg/dL) with lactescent/milky serum
+
100%
false
@@ -52195,6 +54319,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Eruptive cutaneous xanthomas on extensor surfaces and buttocks
+
60–75%
false
@@ -52202,6 +54327,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Recurrent episodes of acute pancreatitis
+
50–65%
false
@@ -52209,6 +54335,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Lipemia retinalis on fundoscopic examination
+
40–55%
false
@@ -52251,6 +54378,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe polyuria (>3–5 L/24h) with dilute urine
+
95–100%
false
@@ -52258,6 +54386,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Compulsive polydipsia / cold water craving
+
95–100%
false
@@ -52265,6 +54394,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Disruptive nocturia
+
90–95%
false
@@ -52272,6 +54402,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypernatremic dehydration when fluid access is restricted
+
40–50%
false
@@ -52664,6 +54795,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Perioral, lingual, and digital paresthesias / tingling
+
85–95%
false
@@ -52671,6 +54803,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Painful carpopedal spasms and cramps
+
70–80%
false
@@ -52678,6 +54811,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Latent tetany: positive Chvostek's sign (60–75%) & Trousseau's sign
+
70–80%
false
@@ -52685,6 +54819,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Laryngospasm and stridor
+
25–35%
false
@@ -52692,6 +54827,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypocalcemic generalized seizures
+
15–25%
false
@@ -52734,6 +54870,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Persistent dull retro-orbital/frontal headache
+
70–85%
false
@@ -52741,6 +54878,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypopituitarism
+
secondary adrenal insufficiency: 65–75%, secondary hypothyroidism: 50–60%, hypogonadism: 50–60%
false
@@ -52748,6 +54886,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Visual field deficits / bitemporal hemianopia due to chiasmal compression
+
45–60%
false
@@ -52755,6 +54894,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Diabetes insipidus (polyuria, polydipsia)
+
20–30%
false
@@ -52797,6 +54937,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Subacute anterograde memory loss and spatial disorientation
+
85–95%
false
@@ -52804,6 +54945,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Temporal lobe complex partial seizures
+
65–75%
false
@@ -52811,6 +54953,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Acute psychiatric disturbances (affective changes, anxiety, psychosis)
+
60–70%
false
@@ -52818,6 +54961,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Disrupted sleep-wake cycles
+
40–50%
false
@@ -53000,6 +55144,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Acute/subacute painful visual loss (unilateral or bilateral)
+
90–100%
false
@@ -53007,6 +55152,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Impaired color vision / dyschromatopsia
+
90–95%
false
@@ -53014,6 +55160,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Retrobulbar pain exacerbated by eye movement
+
85–95%
false
@@ -53021,6 +55168,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Relative afferent pupillary defect (RAPD) and central scotoma
+
75–85%
false
@@ -53147,6 +55295,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Presyncope, lightheadedness, and orthostatic dizziness
+
90–95%
false
@@ -53154,6 +55303,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Palpitations and tremulousness upon standing
+
85–95%
false
@@ -53161,6 +55311,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic fatigue and severe post-exertional exhaustion
+
80–90%
false
@@ -53168,6 +55319,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Cognitive dysfunction ('brain fog')
+
75–85%
false
@@ -53252,6 +55404,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Insidious, progressive exertional dyspnea
+
85–95%
false
@@ -53259,6 +55412,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic, non-productive or mildly productive cough
+
60–75%
false
@@ -53266,6 +55420,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Bibasilar inspiratory crackles
+
50–60%
false
@@ -53273,6 +55428,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Weight loss, low-grade fevers, and cyanosis in advanced disease
+
20–30%
false
@@ -53322,6 +55478,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Painless progressive visual blurriness / decrease in visual acuity
+
80–90%
false
@@ -53329,6 +55486,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Vitreous floaters and haze
+
65–75%
false
@@ -53336,6 +55494,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Visual field scotomas
+
40–50%
false
@@ -53420,6 +55579,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Distal burning neuropathic pain in feet and lower extremities
+
85–95%
false
@@ -53434,6 +55594,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Allodynia, dysesthesias, and hyperalgesia
+
80–90%
false
@@ -53441,6 +55602,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autonomic symptoms (altered sweating, dry mouth/eyes, gastrointestinal dysmotility)
+
50–65%
false
@@ -53623,6 +55785,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Harsh crescendo-decrescendo systolic murmur radiating to carotids
+
90–95%
false
@@ -53630,6 +55793,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Progressive exertional dyspnea
+
75–85%
false
@@ -53637,6 +55801,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Angina pectoris upon exertion
+
40–50%
false
@@ -53644,6 +55809,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Exertional presyncope or syncope
+
20–30%
false
@@ -53791,6 +55957,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Acute progressive external ophthalmoplegia / ophthalmoparesis
+
95–100%
false
@@ -53798,6 +55965,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe central cerebellar and sensory ataxia
+
90–95%
false
@@ -53805,6 +55973,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Altered consciousness / somnolence, stupor, or coma
+
85–95%
false
@@ -53812,6 +55981,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Generalized hypo- or areflexia
+
50–60%
false
@@ -53819,6 +55989,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Pyramidal tract signs / extensor plantar responses (Babinski sign)
+
40–50%
false
@@ -53861,6 +56032,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Creamy yellow-orange hypopigmented choroidal spots radiating from optic disc
+
95–100%
false
@@ -53868,6 +56040,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Vitreous floaters and hazy vision
+
75–85%
false
@@ -53875,6 +56048,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Retinal arteriolar attenuation and vasculitis
+
70–85%
false
@@ -53882,6 +56056,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Bilateral blurred vision / reduced visual acuity
+
70–80%
false
@@ -53889,6 +56064,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Nyctalopia and diminished color discrimination
+
50–65%
false
@@ -53973,6 +56149,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Widespread, tense subepidermal vesicles and bullae on sun-exposed and trunk areas
+
85–95%
false
@@ -53987,6 +56164,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Mucosal blister formation and erosions
+
40–50%
false
@@ -54414,6 +56592,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Early-onset interstitial lung disease / pulmonary hemorrhage
+
90–100%
false
@@ -54421,6 +56600,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic non-erosive inflammatory polyarthritis
+
80–90%
false
@@ -54428,6 +56608,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Recurrent hemoptysis and chronic cough
+
50–60%
false
@@ -54435,6 +56616,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Immune complex-mediated glomerulonephritis
+
40–50%
false
@@ -54547,6 +56729,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypogammaglobulinemia with recurrent sinopulmonary bacterial infections
+
80–90%
false
@@ -54554,6 +56737,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Benign lymphadenopathy and splenomegaly
+
60–70%
false
@@ -54561,6 +56745,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe autoimmune enteropathy / lymphocytic colitis with chronic diarrhea
+
50–60%
false
@@ -54568,6 +56753,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune cytopenias (refractory ITP, AIHA)
+
40–50%
false
@@ -54575,6 +56761,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Lymphocytic interstitial lung disease
+
30–40%
false
@@ -55177,6 +57364,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Unexplained primary or secondary infertility despite regular intercourse
+
95–100%
false
@@ -55513,6 +57701,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Bilateral or unilateral painless lacrimal gland enlargement / dacryoadenitis
+
70–85%
false
@@ -55520,6 +57709,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Upper eyelid fullness, edema, and ptosis
+
60–70%
false
@@ -55527,6 +57717,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Painless proptosis and orbital pseudotumor mass
+
40–55%
false
@@ -55534,6 +57725,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Diplopia due to extraocular muscle enlargement
+
25–35%
false
@@ -55576,6 +57768,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Immune-related maculopapular dermatitis and vitiligo-like depigmentation
+
40–50%
false
@@ -55583,6 +57776,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Immune-mediated colitis with severe watery diarrhea and abdominal cramps
+
30–40%
false
@@ -55590,6 +57784,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune thyroid dysfunction: thyrotoxicosis followed by hypothyroidism
+
15–25%
false
@@ -55597,6 +57792,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune hypophysitis with severe headache and fatigue
+
5–10%
false
@@ -55604,6 +57800,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune hepatitis with marked transaminitis
+
5–10%
false
@@ -55646,6 +57843,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe, intractable, watery secretory diarrhea beginning in early infancy
+
95–100%
false
@@ -55653,6 +57851,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe failure to thrive and cachexia
+
85–95%
false
@@ -55660,6 +57859,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Extensive eczematous or psoriasiform dermatitis
+
70–80%
false
@@ -55667,6 +57867,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Early-onset type 1 diabetes mellitus in male infants
+
60–70%
false
@@ -55674,6 +57875,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune thyroid disease (hypo- or hyperthyroidism)
+
30–40%
false
@@ -55758,6 +57960,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rapidly progressive, symmetric, severe proximal limb weakness
+
90–95%
false
@@ -55772,6 +57975,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe neck flexor weakness and prominent dysphagia
+
50–65%
false
@@ -55779,6 +57983,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Pronounced muscle atrophy and myalgias
+
40–50%
false
@@ -55996,6 +58201,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic, recurrent diarrhea with or without visible blood/mucus
+
80–90%
false
@@ -56003,6 +58209,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Cramping abdominal pain and lower abdominal tenderness
+
70–85%
false
@@ -56010,6 +58217,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rectal urgency, tenesmus, and fecal incontinence
+
50–65%
false
@@ -56017,6 +58225,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Involuntary weight loss, malabsorption, and chronic fatigue
+
50–60%
false
@@ -56024,6 +58233,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Extraintestinal manifestations (peripheral arthritis, uveitis, aphthae)
+
25–35%
false
@@ -56066,6 +58276,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Recurrent, severe spontaneous neuroglycopenic hypoglycemia (confusion, coma, seizures)
+
95–100%
false
@@ -56073,6 +58284,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Sympathetic adrenergic symptoms (sweating, palpitations, tremors)
+
85–95%
false
@@ -56080,6 +58292,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypoglycemia occurring primarily postprandially (2–4 hours after meal) or post-exercise
+
70–80%
false
@@ -56164,6 +58377,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Progressive exertional dyspnea and exercise limitation
+
80–95%
false
@@ -56171,6 +58385,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Bibasilar inspiratory fine Velcro-like crackles
+
75–85%
false
@@ -56178,6 +58393,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Chronic, persistent dry non-productive cough
+
70–85%
false
@@ -56185,6 +58401,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Systemic fatigue, asthenia, and chest tightness
+
70–80%
false
@@ -56192,6 +58409,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Digital clubbing in advanced fibrotic variants
+
20–40%
false
@@ -56485,6 +58703,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Early-onset refractory autoimmune enteropathy with chronic watery diarrhea
+
70–85%
false
@@ -56492,6 +58711,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hypogammaglobulinemia with recurrent severe sinopulmonary infections
+
65–75%
false
@@ -56499,6 +58719,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Massive hepatosplenomegaly and chronic lymphadenopathy
+
60–70%
false
@@ -56506,6 +58727,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Autoimmune cytopenias (autoimmune thrombocytopenia, AIHA)
+
55–65%
false
@@ -56513,6 +58735,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Lymphocytic interstitial lung disease
+
40–50%
false
@@ -56835,6 +59058,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Asymmetric, slowly progressive distal motor weakness without sensory deficits (wrist/finger drop)
+
90–100%
false
@@ -56842,6 +59066,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Asymmetric hyporeflexia confined to clinically weak muscles
+
70–80%
false
@@ -56849,6 +59074,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Muscle fasciculations, myokymia, and muscle cramps
+
60–75%
false
@@ -56856,6 +59082,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Focal muscle atrophy in chronically denervated muscle groups
+
50–65%
false
@@ -57114,6 +59341,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Complete (third-degree) congenital heart block with severe fetal/neonatal bradycardia
+
80–90%
false
@@ -57121,6 +59349,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Photosensitive annular or polycyclic erythematous facial rash ('raccoon/owl eyes')
+
40–50%
false
@@ -57128,6 +59357,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Transient neonatal cholestasis and elevated hepatic transaminases
+
15–25%
false
@@ -57135,6 +59365,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Transient neonatal thrombocytopenia or neutropenia
+
15–20%
false
@@ -57422,6 +59653,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe, painful, refractory polymorphous stomatitis and extensive oral mucosal erosions
+
95–100%
false
@@ -57429,6 +59661,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Polymorphic cutaneous eruptions: lichenoid, bullous, or targetoid lesions
+
80–90%
false
@@ -57436,6 +59669,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe pseudomembranous conjunctivitis and genital erosions
+
70–85%
false
@@ -57443,6 +59677,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Bronchiolitis obliterans leading to progressive, fatal respiratory failure
+
30–40%
false
@@ -57492,6 +59727,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Sudden gross dark reddish-brown / cola-colored urine after cold exposure
+
90–100%
false
@@ -57499,6 +59735,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Acute severe intravascular hemolytic anemia, pallor, and jaundice
+
80–90%
false
@@ -57506,6 +59743,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Abrupt shaking chills, high fever, and back/flank or abdominal pain
+
75–85%
false
@@ -58038,6 +60276,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Marked bilateral dependent peripheral pitting edema and anasarca
+
85–95%
false
@@ -58045,6 +60284,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe hypoalbuminemia (<3.0 g/dL)
+
85–95%
false
@@ -58052,6 +60292,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Heavy nephrotic-range proteinuria (>3.5 g/24h) with foamy urine
+
80–90%
false
@@ -58059,6 +60300,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Hyperlipidemia and lipiduria
+
70–80%
false
@@ -58066,6 +60308,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
High incidence of deep venous thrombosis or renal vein thrombosis
+
10–20%
false
@@ -59228,6 +61471,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe, extensive, photosensitive cutaneous lesions
+
Gottron's papules: 80–90%, heliotrope rash: 70–80%
false
@@ -59235,6 +61479,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Symmetrical proximal muscle weakness
+
70–80%
false
@@ -59242,6 +61487,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Prominent 'V-sign', 'shawl sign', and extensive poikiloderma
+
65–75%
false
@@ -59256,6 +61502,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe dysphagia
+
50–60%
false
@@ -59263,6 +61510,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Palmar hyperkeratotic papules / inverse Gottron's
+
35–45%
false
@@ -59270,6 +61518,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
'Flagellate erythema' on trunk
+
30–40%
false
@@ -59382,6 +61631,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Severe, refractory hyperglycemia despite extreme doses of exogenous insulin (>1,000 U/day)
+
95–100%
false
@@ -59389,6 +61639,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Rapidly progressive, extensive, velvety acanthosis nigricans in skin folds
+
80–90%
false
@@ -59396,6 +61647,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Unexplained marked involuntary weight loss
+
60–70%
false
@@ -59410,6 +61662,7 @@ A third type of PRCA, Diamond-Blackfan syndrome, is due to genetic mutation and
Signs of hyperandrogenism (severe hirsutism, virilization, amenorrhea) in women
+
50–60%
false